The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis

Summary Seminoma and non‐seminoma tumours increasingly occur within the western population. These tumours originate from carcinoma in situ (CIS) cells, which arise from dysfunctional gonocytes. CXCL12 and its receptors, CXCR4 and CXCR7, have been implicated in migration, proliferation and survival o...

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Veröffentlicht in:	Andrology (Oxford) 2013-05, Vol.1 (3), p.517-529
Hauptverfasser:	McIver, S. C., Loveland, K. L., Roman, S. D., Nixon, B., Kitazawa, R., McLaughlin, E. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line, Tumor Chemokine CXCL12 - physiology differentiation Fundamental and applied biological sciences. Psychology germ cell tumours gonocyte Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Mammalian male genital system Medical sciences Metastasis Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Metastasis primordial germ cell Receptors, CXCR4 - physiology Rodents Seminoma - pathology seminoma and non‐seminoma spermatogenesis spermatogonia Tumors Vertebrates: reproduction
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