Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study
Summary Background In gastro‐oesophageal reflux disease (GERD), heartburn responds well to acid suppression, but regurgitation is a common cause of incomplete treatment response. Aim To assess the prevalence and burden of persistent, frequent regurgitation in primary care patients with GERD treated...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2013-05, Vol.37 (10), p.1005-1010 |
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| creator | Kahrilas, P. J. Howden, C. W. Wernersson, B. Denison, H. Nuevo, J. Gisbert, J. P. |
| description | Summary
Background
In gastro‐oesophageal reflux disease (GERD), heartburn responds well to acid suppression, but regurgitation is a common cause of incomplete treatment response.
Aim
To assess the prevalence and burden of persistent, frequent regurgitation in primary care patients with GERD treated with acid suppression.
Methods
We analysed observational data from 134 sites across six European countries in patients diagnosed with GERD. Within 3 months of the index visit, symptoms were assessed using the Reflux Disease Questionnaire, and their impact on sleep and work productivity with the Quality of Life in Reflux and Dyspepsia questionnaire and the Work Productivity and Activity Impairment Questionnaire, respectively. Patients provided information on concomitant over‐the‐counter (OTC) GERD medication use.
Results
Persistent, frequent (3–7 days/week) regurgitation was reported by 13.2% (153/1156) of GERD patients with no heartburn on acid suppression; the prevalence was very similar for patients with up to 2 days/week of ongoing mild heartburn. Among patients without heartburn, sleep disturbance of any type was reported by 50.7–60.1% with persistent, frequent regurgitation, compared with 38.1–51.1% and 14.4–19.2% of those with less frequent or no regurgitation respectively. Persistent, frequent regurgitation was associated with increased use of OTC medication and more hours of work missed, whether mild, infrequent heartburn was present or not.
Conclusions
Frequent regurgitation, which persisted in 12–13% of patients with no or infrequent, mild heartburn on acid suppression, negatively affected sleep and work productivity, and increased use of OTC medication. Persistent, frequent regurgitation is problematic for primary care patients with GERD. |
| doi_str_mv | 10.1111/apt.12298 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1328542758</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1328542758</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3908-e7095e2b2d502fbd4e574e3e0633ab04942c9c176580a46a976bf43d253327d83</originalsourceid><addsrcrecordid>eNp1kctu1DAUhi0EokNhwQsgb5BAIq0vcZywqyqglSq1i7KOTuyT1si51BdV8yi8LZ7OQFfYlo4Xn79j-yfkPWcnvIxTWNMJF6JrX5ANl42qBJPNS7Jhoukq0XJ5RN7E-Isx1mgmXpMjIZXSTLcb8vtyWsEkuox0xRBdTDinL3QM-JDLjga8y-HOJUhumWlZDxm8S9vdAe9GpG6m9wghDTnMhY7rMtsioikgJLT00aV7CsZZGvO6FiAW0VcKdMo-ufnJC56uwU0QttRAQBpTttu35NUIPuK7Qz0mP79_uz2_qK6uf1yen11VRnasrVCzTqEYhFVMjIOtUekaJbJGShhY3dXCdIbrRrUM6gY63QxjLa1QUgptW3lMPu29a1jKm2PqJxcNeg8zLjn2XIpW1UKrHfp5j5qwxBhw7A_X7jnrd0n0JYn-KYnCfjho8zCh_Uf-_foCfDwAEA34McBsXHzmtKjL5IU73XOPzuP2_x37s5vbfes_nf2ilw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1328542758</pqid></control><display><type>article</type><title>Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><creator>Kahrilas, P. J. ; Howden, C. W. ; Wernersson, B. ; Denison, H. ; Nuevo, J. ; Gisbert, J. P.</creator><creatorcontrib>Kahrilas, P. J. ; Howden, C. W. ; Wernersson, B. ; Denison, H. ; Nuevo, J. ; Gisbert, J. P.</creatorcontrib><description>Summary
Background
In gastro‐oesophageal reflux disease (GERD), heartburn responds well to acid suppression, but regurgitation is a common cause of incomplete treatment response.
Aim
To assess the prevalence and burden of persistent, frequent regurgitation in primary care patients with GERD treated with acid suppression.
Methods
We analysed observational data from 134 sites across six European countries in patients diagnosed with GERD. Within 3 months of the index visit, symptoms were assessed using the Reflux Disease Questionnaire, and their impact on sleep and work productivity with the Quality of Life in Reflux and Dyspepsia questionnaire and the Work Productivity and Activity Impairment Questionnaire, respectively. Patients provided information on concomitant over‐the‐counter (OTC) GERD medication use.
Results
Persistent, frequent (3–7 days/week) regurgitation was reported by 13.2% (153/1156) of GERD patients with no heartburn on acid suppression; the prevalence was very similar for patients with up to 2 days/week of ongoing mild heartburn. Among patients without heartburn, sleep disturbance of any type was reported by 50.7–60.1% with persistent, frequent regurgitation, compared with 38.1–51.1% and 14.4–19.2% of those with less frequent or no regurgitation respectively. Persistent, frequent regurgitation was associated with increased use of OTC medication and more hours of work missed, whether mild, infrequent heartburn was present or not.
Conclusions
Frequent regurgitation, which persisted in 12–13% of patients with no or infrequent, mild heartburn on acid suppression, negatively affected sleep and work productivity, and increased use of OTC medication. Persistent, frequent regurgitation is problematic for primary care patients with GERD.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.12298</identifier><identifier>PMID: 23557078</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cross-Sectional Studies ; Digestive system ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - complications ; Gastroesophageal Reflux - drug therapy ; Gastroesophageal Reflux - psychology ; Gastrointestinal Agents - therapeutic use ; Health Status ; Heartburn - drug therapy ; Heartburn - etiology ; Heartburn - psychology ; Humans ; Hydrogen-Ion Concentration ; Laryngopharyngeal Reflux - etiology ; Laryngopharyngeal Reflux - psychology ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Primary Health Care ; Quality of Life - psychology ; Severity of Illness Index ; Sleep Wake Disorders - etiology ; Surveys and Questionnaires</subject><ispartof>Alimentary pharmacology & therapeutics, 2013-05, Vol.37 (10), p.1005-1010</ispartof><rights>2013 Blackwell Publishing Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2013 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3908-e7095e2b2d502fbd4e574e3e0633ab04942c9c176580a46a976bf43d253327d83</citedby><cites>FETCH-LOGICAL-c3908-e7095e2b2d502fbd4e574e3e0633ab04942c9c176580a46a976bf43d253327d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.12298$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.12298$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27242421$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23557078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kahrilas, P. J.</creatorcontrib><creatorcontrib>Howden, C. W.</creatorcontrib><creatorcontrib>Wernersson, B.</creatorcontrib><creatorcontrib>Denison, H.</creatorcontrib><creatorcontrib>Nuevo, J.</creatorcontrib><creatorcontrib>Gisbert, J. P.</creatorcontrib><title>Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
In gastro‐oesophageal reflux disease (GERD), heartburn responds well to acid suppression, but regurgitation is a common cause of incomplete treatment response.
Aim
To assess the prevalence and burden of persistent, frequent regurgitation in primary care patients with GERD treated with acid suppression.
Methods
We analysed observational data from 134 sites across six European countries in patients diagnosed with GERD. Within 3 months of the index visit, symptoms were assessed using the Reflux Disease Questionnaire, and their impact on sleep and work productivity with the Quality of Life in Reflux and Dyspepsia questionnaire and the Work Productivity and Activity Impairment Questionnaire, respectively. Patients provided information on concomitant over‐the‐counter (OTC) GERD medication use.
Results
Persistent, frequent (3–7 days/week) regurgitation was reported by 13.2% (153/1156) of GERD patients with no heartburn on acid suppression; the prevalence was very similar for patients with up to 2 days/week of ongoing mild heartburn. Among patients without heartburn, sleep disturbance of any type was reported by 50.7–60.1% with persistent, frequent regurgitation, compared with 38.1–51.1% and 14.4–19.2% of those with less frequent or no regurgitation respectively. Persistent, frequent regurgitation was associated with increased use of OTC medication and more hours of work missed, whether mild, infrequent heartburn was present or not.
Conclusions
Frequent regurgitation, which persisted in 12–13% of patients with no or infrequent, mild heartburn on acid suppression, negatively affected sleep and work productivity, and increased use of OTC medication. Persistent, frequent regurgitation is problematic for primary care patients with GERD.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Digestive system</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Gastroesophageal Reflux - drug therapy</subject><subject>Gastroesophageal Reflux - psychology</subject><subject>Gastrointestinal Agents - therapeutic use</subject><subject>Health Status</subject><subject>Heartburn - drug therapy</subject><subject>Heartburn - etiology</subject><subject>Heartburn - psychology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Laryngopharyngeal Reflux - etiology</subject><subject>Laryngopharyngeal Reflux - psychology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Primary Health Care</subject><subject>Quality of Life - psychology</subject><subject>Severity of Illness Index</subject><subject>Sleep Wake Disorders - etiology</subject><subject>Surveys and Questionnaires</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1DAUhi0EokNhwQsgb5BAIq0vcZywqyqglSq1i7KOTuyT1si51BdV8yi8LZ7OQFfYlo4Xn79j-yfkPWcnvIxTWNMJF6JrX5ANl42qBJPNS7Jhoukq0XJ5RN7E-Isx1mgmXpMjIZXSTLcb8vtyWsEkuox0xRBdTDinL3QM-JDLjga8y-HOJUhumWlZDxm8S9vdAe9GpG6m9wghDTnMhY7rMtsioikgJLT00aV7CsZZGvO6FiAW0VcKdMo-ufnJC56uwU0QttRAQBpTttu35NUIPuK7Qz0mP79_uz2_qK6uf1yen11VRnasrVCzTqEYhFVMjIOtUekaJbJGShhY3dXCdIbrRrUM6gY63QxjLa1QUgptW3lMPu29a1jKm2PqJxcNeg8zLjn2XIpW1UKrHfp5j5qwxBhw7A_X7jnrd0n0JYn-KYnCfjho8zCh_Uf-_foCfDwAEA34McBsXHzmtKjL5IU73XOPzuP2_x37s5vbfes_nf2ilw</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Kahrilas, P. J.</creator><creator>Howden, C. W.</creator><creator>Wernersson, B.</creator><creator>Denison, H.</creator><creator>Nuevo, J.</creator><creator>Gisbert, J. P.</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study</title><author>Kahrilas, P. J. ; Howden, C. W. ; Wernersson, B. ; Denison, H. ; Nuevo, J. ; Gisbert, J. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3908-e7095e2b2d502fbd4e574e3e0633ab04942c9c176580a46a976bf43d253327d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Digestive system</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Gastroesophageal Reflux - drug therapy</topic><topic>Gastroesophageal Reflux - psychology</topic><topic>Gastrointestinal Agents - therapeutic use</topic><topic>Health Status</topic><topic>Heartburn - drug therapy</topic><topic>Heartburn - etiology</topic><topic>Heartburn - psychology</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Laryngopharyngeal Reflux - etiology</topic><topic>Laryngopharyngeal Reflux - psychology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Primary Health Care</topic><topic>Quality of Life - psychology</topic><topic>Severity of Illness Index</topic><topic>Sleep Wake Disorders - etiology</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kahrilas, P. J.</creatorcontrib><creatorcontrib>Howden, C. W.</creatorcontrib><creatorcontrib>Wernersson, B.</creatorcontrib><creatorcontrib>Denison, H.</creatorcontrib><creatorcontrib>Nuevo, J.</creatorcontrib><creatorcontrib>Gisbert, J. P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kahrilas, P. J.</au><au>Howden, C. W.</au><au>Wernersson, B.</au><au>Denison, H.</au><au>Nuevo, J.</au><au>Gisbert, J. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2013-05</date><risdate>2013</risdate><volume>37</volume><issue>10</issue><spage>1005</spage><epage>1010</epage><pages>1005-1010</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
In gastro‐oesophageal reflux disease (GERD), heartburn responds well to acid suppression, but regurgitation is a common cause of incomplete treatment response.
Aim
To assess the prevalence and burden of persistent, frequent regurgitation in primary care patients with GERD treated with acid suppression.
Methods
We analysed observational data from 134 sites across six European countries in patients diagnosed with GERD. Within 3 months of the index visit, symptoms were assessed using the Reflux Disease Questionnaire, and their impact on sleep and work productivity with the Quality of Life in Reflux and Dyspepsia questionnaire and the Work Productivity and Activity Impairment Questionnaire, respectively. Patients provided information on concomitant over‐the‐counter (OTC) GERD medication use.
Results
Persistent, frequent (3–7 days/week) regurgitation was reported by 13.2% (153/1156) of GERD patients with no heartburn on acid suppression; the prevalence was very similar for patients with up to 2 days/week of ongoing mild heartburn. Among patients without heartburn, sleep disturbance of any type was reported by 50.7–60.1% with persistent, frequent regurgitation, compared with 38.1–51.1% and 14.4–19.2% of those with less frequent or no regurgitation respectively. Persistent, frequent regurgitation was associated with increased use of OTC medication and more hours of work missed, whether mild, infrequent heartburn was present or not.
Conclusions
Frequent regurgitation, which persisted in 12–13% of patients with no or infrequent, mild heartburn on acid suppression, negatively affected sleep and work productivity, and increased use of OTC medication. Persistent, frequent regurgitation is problematic for primary care patients with GERD.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>23557078</pmid><doi>10.1111/apt.12298</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| subjects | Adult Aged Biological and medical sciences Cross-Sectional Studies Digestive system Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - complications Gastroesophageal Reflux - drug therapy Gastroesophageal Reflux - psychology Gastrointestinal Agents - therapeutic use Health Status Heartburn - drug therapy Heartburn - etiology Heartburn - psychology Humans Hydrogen-Ion Concentration Laryngopharyngeal Reflux - etiology Laryngopharyngeal Reflux - psychology Medical sciences Middle Aged Pharmacology. Drug treatments Primary Health Care Quality of Life - psychology Severity of Illness Index Sleep Wake Disorders - etiology Surveys and Questionnaires |
| title | Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study |
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