Post-insult Ibuprofen Treatment Attenuates Damage to the Serotonergic System After Hypoxia-Ischemia in the Immature Rat Brain

ABSTRACTThere is currently no therapeutic intervention to stem neonatal brain injury after exposure to hypoxia-ischemia (HI). Potential neuroprotective treatments that can be delivered postinsult that target neuroinflammation and are safe to use in neonates are attractive. One candidate is ibuprofen...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2012-12, Vol.71 (12), p.1137-1148
Hauptverfasser:	Wixey, Julie A, Reinebrant, Hanna E, Buller, Kathryn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology Brain damage Brain Injuries - drug therapy Brain Injuries - etiology Brain Injuries - pathology Calcium-Binding Proteins - metabolism Cyclooxygenase 2 - metabolism Cytokines - metabolism Disease Models, Animal Drug Administration Schedule Drug dosages Enzyme-Linked Immunosorbent Assay Functional Laterality Human viral diseases Hypoxia Hypoxia-Ischemia, Brain - complications Ibuprofen - therapeutic use Infectious diseases Intervention Ischemia Medical sciences Microfilament Proteins - metabolism Mortality Neural networks Neurology Nonsteroidal anti-inflammatory drugs Proteins Rats Rats, Sprague-Dawley Rodents Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - metabolism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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