The genesis and unique properties of the lymphovascular tumor embolus are because of calpain-regulated proteolysis of E-cadherin

The genesis and unique properties of the lymphovascular tumor embolus are poorly understood largely because of the absence of an experimental model that specifically reflects this important step of tumor progression. The lymphovascular tumor embolus is a blastocyst-like structure resistant to chemot...

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Veröffentlicht in:	Oncogene 2013-03, Vol.32 (13), p.1702-1713
Hauptverfasser:	Ye, Y, Tian, H, Lange, A R, Yearsley, K, Robertson, F M, Barsky, S H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 631/67/322 631/80/474 Adherens junctions Amino Acid Sequence Animals Apoptosis Binding sites Blood Vessels - metabolism Blood Vessels - pathology Breast cancer Cadherins Cadherins - chemistry Cadherins - metabolism Cadherins - physiology Calpain Calpain - metabolism Calpain - physiology Carcinoma - blood supply Carcinoma - complications Carcinoma - metabolism Carcinoma - pathology Cell Adhesion Cell adhesion & migration Cell Biology Cell Line, Tumor Cell Survival Chemotherapy E-cadherin Embolism Embolism - etiology Embolism - metabolism Embolism - pathology Female Genetic aspects Human Genetics Humans Inflammation Inflammatory Breast Neoplasms - blood supply Inflammatory Breast Neoplasms - complications Inflammatory Breast Neoplasms - metabolism Inflammatory Breast Neoplasms - pathology Internal Medicine Lymphatic system Lymphatic Vessels - metabolism Lymphatic Vessels - pathology Matrix metalloproteinase Medicine Medicine & Public Health Mesenchyme Metalloproteinase Metastases Metastasis Models, Biological Molecular Sequence Data Neoplasm Metastasis Neoplasms - blood supply Neoplasms - complications Neoplasms - genetics Neoplasms - metabolism Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Oncology original-article Physiological aspects Proteolysis Risk factors Secretase Spheroids Transplantation, Heterologous Tumor suppressor genes Tumors Xenografts β-Catenin
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