Semaphorins 3A and 7A: potential immune and neuroregenerative targets in multiple sclerosis
Semaphorins have been classically defined as axonal signalling cues involved in central nervous system (CNS) development, but in adults these molecules are expressed in distinct tissues and exert various functions under several physiological and pathological contexts. Semaphorins capable of modulati...
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| Veröffentlicht in: | Trends in molecular medicine 2013-03, Vol.19 (3), p.157-164 |
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| creator | Eixarch, Herena Gutiérrez-Franco, Ana Montalban, Xavier Espejo, Carmen |
| description | Semaphorins have been classically defined as axonal signalling cues involved in central nervous system (CNS) development, but in adults these molecules are expressed in distinct tissues and exert various functions under several physiological and pathological contexts. Semaphorins capable of modulating the immune system are particularly relevant in autoimmune diseases, especially multiple sclerosis (MS), which is a demyelinating, neurodegenerative disease. In this article, we compile recent insights into the specific roles of semaphorin (sema)3A and sema7A to clarify the details of their possible participation in the inflammatory and neurodegenerative phases of MS. |
| doi_str_mv | 10.1016/j.molmed.2013.01.003 |
| format | Article |
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Semaphorins capable of modulating the immune system are particularly relevant in autoimmune diseases, especially multiple sclerosis (MS), which is a demyelinating, neurodegenerative disease. In this article, we compile recent insights into the specific roles of semaphorin (sema)3A and sema7A to clarify the details of their possible participation in the inflammatory and neurodegenerative phases of MS.</description><identifier>ISSN: 1471-4914</identifier><identifier>EISSN: 1471-499X</identifier><identifier>DOI: 10.1016/j.molmed.2013.01.003</identifier><identifier>PMID: 23419749</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Animals ; Axons ; Disease Models, Animal ; experimental autoimmune encephalomyelitis ; Humans ; Immunomodulation ; multiple sclerosis ; Multiple Sclerosis - immunology ; Multiple Sclerosis - physiopathology ; neurodegeneration ; neuroregeneration ; Pathology ; semaphorin ; Semaphorin-3A - immunology ; Semaphorin-3A - metabolism ; Semaphorins - immunology ; Semaphorins - metabolism ; Signal Transduction</subject><ispartof>Trends in molecular medicine, 2013-03, Vol.19 (3), p.157-164</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. 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Semaphorins capable of modulating the immune system are particularly relevant in autoimmune diseases, especially multiple sclerosis (MS), which is a demyelinating, neurodegenerative disease. 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Animals Axons Disease Models, Animal experimental autoimmune encephalomyelitis Humans Immunomodulation multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - physiopathology neurodegeneration neuroregeneration Pathology semaphorin Semaphorin-3A - immunology Semaphorin-3A - metabolism Semaphorins - immunology Semaphorins - metabolism Signal Transduction |
| title | Semaphorins 3A and 7A: potential immune and neuroregenerative targets in multiple sclerosis |
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