Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors

[Display omitted] ► A series of pinanamine derivatives were design and synthesized for M2 inhibitors. ► Several imidazole and guanazole substituted compounds were found to inhibit WT A/M2 as potent as amantadine. ► Compound 12 was identified to be a novel inhibitor against both A/M2-WT and A/M2-S31N...

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