Behavioral effects of Rho GTPase modulation in a model of Alzheimer's disease

► Cerebral Rho GTPases are critically involved in cognitive functions. ► We modulated Rho GTPase signalling in TgCRND8 mice, a model of Alzheimer's disease. ► TgCRND8 mice show deficits in reversal learning in a water maze task and increased locomotor activity in an open field. ► The Rho GTPase...

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Veröffentlicht in:	Behavioural brain research 2013-01, Vol.237, p.223-229
Hauptverfasser:	Musilli, Marco, Nicolia, Vincenzina, Borrelli, Sonia, Scarpa, Sigfrido, Diana, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Protein Precursor - genetics Analysis of Variance Animals Bacterial toxins Bacterial Toxins - therapeutic use Behavior Behavioral psychophysiology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Drug therapy Enzyme Activators - therapeutic use Escherichia coli Proteins - therapeutic use Exploratory Behavior - drug effects Exploratory Behavior - physiology Fundamental and applied biological sciences. Psychology Humans Learning Disorders - drug therapy Learning Disorders - enzymology Learning Disorders - etiology Maze Learning - drug effects Maze Learning - physiology Medical sciences Mice Mice, Transgenic Motor Activity - drug effects Motor Activity - genetics Mutation - genetics Neurology Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry rho GTP-Binding Proteins - metabolism Rotarod Rotarod Performance Test Transgenic
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