Comprehensive treatment of malignant mesothelioma patients after the failure of systemic chemotherapy
► We studied malignant mesothelioma patients in whom systemic chemotherapy had failed. ► One group received cryosurgery, photodynamic therapy and intracavity chemotherapy. ► Patients who received intracavity chemotherapy only comprised the control group. ► Overall survival (OS) was significantly gre...
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| Veröffentlicht in: | Cryobiology 2012-12, Vol.65 (3), p.284-288 |
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| creator | Chen, Jibing Liang, Bing Yuan, Yuanying Liu, Chunyan Li, Li Li, Haibo Mu, Feng Zuo, Jiansheng Xu, Kecheng |
| description | ► We studied malignant mesothelioma patients in whom systemic chemotherapy had failed. ► One group received cryosurgery, photodynamic therapy and intracavity chemotherapy. ► Patients who received intracavity chemotherapy only comprised the control group. ► Overall survival (OS) was significantly greater with the combined treatment. ► Increased OS was closely associated with repeated treatment.
Malignant mesothelioma (MM) is an aggressive neoplasm usually arising from the mesothelial surfaces of the pleural or peritoneal cavity. Currently, no standard therapy is available. The most commonly used therapy is cytoreductive surgery combined with systematic chemotherapy, but the median overall survival (OS) is less than 12months; moreover, treatments are lacking for patients in whom chemotherapy has failed and/or who cannot withstand surgery. We investigated multiple minimally invasive therapies (cryosurgery, photodynamic therapy and intracavity chemotherapy) for the treatment of MM patients in whom systemic chemotherapy had failed. Twenty-seven patients were divided into comprehensive (combination of the three therapies) and palliative (intracavity chemotherapy only) treatment groups. The OS of patients who received comprehensive treatment was significantly longer than that of those who received palliative treatment (median OS: 64 vs. 9months, P |
| doi_str_mv | 10.1016/j.cryobiol.2012.08.003 |
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Malignant mesothelioma (MM) is an aggressive neoplasm usually arising from the mesothelial surfaces of the pleural or peritoneal cavity. Currently, no standard therapy is available. The most commonly used therapy is cytoreductive surgery combined with systematic chemotherapy, but the median overall survival (OS) is less than 12months; moreover, treatments are lacking for patients in whom chemotherapy has failed and/or who cannot withstand surgery. We investigated multiple minimally invasive therapies (cryosurgery, photodynamic therapy and intracavity chemotherapy) for the treatment of MM patients in whom systemic chemotherapy had failed. Twenty-seven patients were divided into comprehensive (combination of the three therapies) and palliative (intracavity chemotherapy only) treatment groups. The OS of patients who received comprehensive treatment was significantly longer than that of those who received palliative treatment (median OS: 64 vs. 9months, P<0.001). This interesting result was not associated with treatment timing, but was closely associated with repeated treatments.</description><identifier>ISSN: 0011-2240</identifier><identifier>EISSN: 1090-2392</identifier><identifier>DOI: 10.1016/j.cryobiol.2012.08.003</identifier><identifier>PMID: 22939880</identifier><identifier>CODEN: CRYBAS</identifier><language>eng</language><publisher>Kidlington: Elsevier Inc</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Combined Modality Therapy ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Cryosurgery ; Female ; Humans ; Intracavity chemotherapy ; Male ; Medical sciences ; Mesothelioma ; Mesothelioma - drug therapy ; Mesothelioma - surgery ; Middle Aged ; Minimally invasive surgery ; Palliative Care ; Pharmacology. Drug treatments ; Photochemotherapy ; Retrospective Studies ; Survival Analysis</subject><ispartof>Cryobiology, 2012-12, Vol.65 (3), p.284-288</ispartof><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-2ec035ae58a96ff8fea8a0aca59a27fd458a5783b458fd21c0d2b63878ca17993</citedby><cites>FETCH-LOGICAL-c464t-2ec035ae58a96ff8fea8a0aca59a27fd458a5783b458fd21c0d2b63878ca17993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0011224012002222$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26691976$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22939880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jibing</creatorcontrib><creatorcontrib>Liang, Bing</creatorcontrib><creatorcontrib>Yuan, Yuanying</creatorcontrib><creatorcontrib>Liu, Chunyan</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Li, Haibo</creatorcontrib><creatorcontrib>Mu, Feng</creatorcontrib><creatorcontrib>Zuo, Jiansheng</creatorcontrib><creatorcontrib>Xu, Kecheng</creatorcontrib><title>Comprehensive treatment of malignant mesothelioma patients after the failure of systemic chemotherapy</title><title>Cryobiology</title><addtitle>Cryobiology</addtitle><description>► We studied malignant mesothelioma patients in whom systemic chemotherapy had failed. ► One group received cryosurgery, photodynamic therapy and intracavity chemotherapy. ► Patients who received intracavity chemotherapy only comprised the control group. ► Overall survival (OS) was significantly greater with the combined treatment. ► Increased OS was closely associated with repeated treatment.
Malignant mesothelioma (MM) is an aggressive neoplasm usually arising from the mesothelial surfaces of the pleural or peritoneal cavity. Currently, no standard therapy is available. The most commonly used therapy is cytoreductive surgery combined with systematic chemotherapy, but the median overall survival (OS) is less than 12months; moreover, treatments are lacking for patients in whom chemotherapy has failed and/or who cannot withstand surgery. We investigated multiple minimally invasive therapies (cryosurgery, photodynamic therapy and intracavity chemotherapy) for the treatment of MM patients in whom systemic chemotherapy had failed. Twenty-seven patients were divided into comprehensive (combination of the three therapies) and palliative (intracavity chemotherapy only) treatment groups. The OS of patients who received comprehensive treatment was significantly longer than that of those who received palliative treatment (median OS: 64 vs. 9months, P<0.001). This interesting result was not associated with treatment timing, but was closely associated with repeated treatments.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Cryosurgery</subject><subject>Female</subject><subject>Humans</subject><subject>Intracavity chemotherapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesothelioma</subject><subject>Mesothelioma - drug therapy</subject><subject>Mesothelioma - surgery</subject><subject>Middle Aged</subject><subject>Minimally invasive surgery</subject><subject>Palliative Care</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Photochemotherapy</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jibing</creatorcontrib><creatorcontrib>Liang, Bing</creatorcontrib><creatorcontrib>Yuan, Yuanying</creatorcontrib><creatorcontrib>Liu, Chunyan</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Li, Haibo</creatorcontrib><creatorcontrib>Mu, Feng</creatorcontrib><creatorcontrib>Zuo, Jiansheng</creatorcontrib><creatorcontrib>Xu, Kecheng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Cryobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jibing</au><au>Liang, Bing</au><au>Yuan, Yuanying</au><au>Liu, Chunyan</au><au>Li, Li</au><au>Li, Haibo</au><au>Mu, Feng</au><au>Zuo, Jiansheng</au><au>Xu, Kecheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive treatment of malignant mesothelioma patients after the failure of systemic chemotherapy</atitle><jtitle>Cryobiology</jtitle><addtitle>Cryobiology</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>65</volume><issue>3</issue><spage>284</spage><epage>288</epage><pages>284-288</pages><issn>0011-2240</issn><eissn>1090-2392</eissn><coden>CRYBAS</coden><abstract>► We studied malignant mesothelioma patients in whom systemic chemotherapy had failed. ► One group received cryosurgery, photodynamic therapy and intracavity chemotherapy. ► Patients who received intracavity chemotherapy only comprised the control group. ► Overall survival (OS) was significantly greater with the combined treatment. ► Increased OS was closely associated with repeated treatment.
Malignant mesothelioma (MM) is an aggressive neoplasm usually arising from the mesothelial surfaces of the pleural or peritoneal cavity. Currently, no standard therapy is available. The most commonly used therapy is cytoreductive surgery combined with systematic chemotherapy, but the median overall survival (OS) is less than 12months; moreover, treatments are lacking for patients in whom chemotherapy has failed and/or who cannot withstand surgery. We investigated multiple minimally invasive therapies (cryosurgery, photodynamic therapy and intracavity chemotherapy) for the treatment of MM patients in whom systemic chemotherapy had failed. Twenty-seven patients were divided into comprehensive (combination of the three therapies) and palliative (intracavity chemotherapy only) treatment groups. The OS of patients who received comprehensive treatment was significantly longer than that of those who received palliative treatment (median OS: 64 vs. 9months, P<0.001). This interesting result was not associated with treatment timing, but was closely associated with repeated treatments.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>22939880</pmid><doi>10.1016/j.cryobiol.2012.08.003</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cryosurgery Female Humans Intracavity chemotherapy Male Medical sciences Mesothelioma Mesothelioma - drug therapy Mesothelioma - surgery Middle Aged Minimally invasive surgery Palliative Care Pharmacology. Drug treatments Photochemotherapy Retrospective Studies Survival Analysis |
| title | Comprehensive treatment of malignant mesothelioma patients after the failure of systemic chemotherapy |
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