Solid-Phase Colorimetric Sensor Based on Gold Nanoparticle-Loaded Polymer Brushes: Lead Detection as a Case Study
We introduce a novel solid-phase colorimetric sensor facilely fabricated by loading unmodified gold nanoparticles into poly(oligo(ethylene glycol)methacrylate) (POEGMA) brushes grown on glass. Our work reports the first synergistic combination of metallic nanoparticles acting as a colorimetric sensi...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2013-04, Vol.85 (8), p.4094-4099 |
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| container_issue | 8 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Ferhan, Abdul Rahim Guo, Longhua Zhou, Xiaodong Chen, Peng Hong, Seungpyo Kim, Dong-Hwan |
| description | We introduce a novel solid-phase colorimetric sensor facilely fabricated by loading unmodified gold nanoparticles into poly(oligo(ethylene glycol)methacrylate) (POEGMA) brushes grown on glass. Our work reports the first synergistic combination of metallic nanoparticles acting as a colorimetric sensing module with a nonfouling polymer matrix acting both as a nonrigid scaffold and a screen to reduce interference from nontarget molecules. In addition, as the nanocomposite is formed on a transparent substrate, solid-phase detection can be performed in the same manner as in the solution-phase. We demonstrate the use of this unique platform for label-free lead detection based on the release of gold nanoparticles from the polymer brush upon exposure to lead ions. An ultralow limit-of-detection of 25 pM (S/N = 3) and a dynamic range of 100 pM to 100 nM (R 2 = 0.987) are achieved. Furthermore, the detection is up to 1000-fold more selective to lead over other common heavy metal ions. |
| doi_str_mv | 10.1021/ac4001817 |
| format | Article |
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Furthermore, the detection is up to 1000-fold more selective to lead over other common heavy metal ions.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac4001817</identifier><identifier>PMID: 23509859</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Analytical chemistry ; Electrochemical Techniques - methods ; Glass ; Gold ; Gold - chemistry ; Humans ; Ions ; Lead - blood ; Limit of Detection ; Metal Nanoparticles - chemistry ; Methacrylates - chemistry ; Nanoparticles ; Phase transitions ; Polyethylene Glycols - chemistry ; Polymers ; Sensors</subject><ispartof>Analytical chemistry (Washington), 2013-04, Vol.85 (8), p.4094-4099</ispartof><rights>Copyright © 2013 American Chemical Society</rights><rights>Copyright American Chemical Society Apr 16, 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a409t-b2724fe471ed29e52021ceecb4029502cd4a46ebb3b40a28aa08f2bc7d12427d3</citedby><cites>FETCH-LOGICAL-a409t-b2724fe471ed29e52021ceecb4029502cd4a46ebb3b40a28aa08f2bc7d12427d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac4001817$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac4001817$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23509859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferhan, Abdul Rahim</creatorcontrib><creatorcontrib>Guo, Longhua</creatorcontrib><creatorcontrib>Zhou, Xiaodong</creatorcontrib><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Hong, Seungpyo</creatorcontrib><creatorcontrib>Kim, Dong-Hwan</creatorcontrib><title>Solid-Phase Colorimetric Sensor Based on Gold Nanoparticle-Loaded Polymer Brushes: Lead Detection as a Case Study</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>We introduce a novel solid-phase colorimetric sensor facilely fabricated by loading unmodified gold nanoparticles into poly(oligo(ethylene glycol)methacrylate) (POEGMA) brushes grown on glass. Our work reports the first synergistic combination of metallic nanoparticles acting as a colorimetric sensing module with a nonfouling polymer matrix acting both as a nonrigid scaffold and a screen to reduce interference from nontarget molecules. In addition, as the nanocomposite is formed on a transparent substrate, solid-phase detection can be performed in the same manner as in the solution-phase. We demonstrate the use of this unique platform for label-free lead detection based on the release of gold nanoparticles from the polymer brush upon exposure to lead ions. An ultralow limit-of-detection of 25 pM (S/N = 3) and a dynamic range of 100 pM to 100 nM (R 2 = 0.987) are achieved. Furthermore, the detection is up to 1000-fold more selective to lead over other common heavy metal ions.</description><subject>Analytical chemistry</subject><subject>Electrochemical Techniques - methods</subject><subject>Glass</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Ions</subject><subject>Lead - blood</subject><subject>Limit of Detection</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Methacrylates - chemistry</subject><subject>Nanoparticles</subject><subject>Phase transitions</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymers</subject><subject>Sensors</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0VFP2zAQB3ALbYJSeNgXmCxNk-AhcL4kjbO3rTA2qQKkwnN0sa9qqjQudvLQb4-rFoS2J0u-n_-274T4ouBKAaprMhmA0qo4EiOVIyQTrfGTGAFAmmABcCJOQ1hFo0BNjsUJpjmUOi9H4mXu2sYmj0sKLKeudb5Zc-8bI-fcBeflr1iw0nXyzrVW3lPnNuT7xrSczBzZWHt07XbNUfohLDn8kDMmK2-4Z9M38SAFSXK6y5_3g92eic8LagOfH9axeP59-zT9k8we7v5Of84SyqDskxoLzBacFYotlhx_hcowmzoDLHNAYzPKJlzXadwh1ESgF1ibwirMsLDpWFzsczfevQwc-mrdBMNtSx27IVQqRY2xOWUa6bd_6MoNvouv26lS6RxzHdXlXhnvQvC8qDaxWeS3lYJqN4fqfQ7Rfj0kDvWa7bt8a3wE3_eATPhw239Br8cpjMM</recordid><startdate>20130416</startdate><enddate>20130416</enddate><creator>Ferhan, Abdul Rahim</creator><creator>Guo, Longhua</creator><creator>Zhou, Xiaodong</creator><creator>Chen, Peng</creator><creator>Hong, Seungpyo</creator><creator>Kim, Dong-Hwan</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20130416</creationdate><title>Solid-Phase Colorimetric Sensor Based on Gold Nanoparticle-Loaded Polymer Brushes: Lead Detection as a Case Study</title><author>Ferhan, Abdul Rahim ; 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| source | MEDLINE; American Chemical Society Journals |
| subjects | Analytical chemistry Electrochemical Techniques - methods Glass Gold Gold - chemistry Humans Ions Lead - blood Limit of Detection Metal Nanoparticles - chemistry Methacrylates - chemistry Nanoparticles Phase transitions Polyethylene Glycols - chemistry Polymers Sensors |
| title | Solid-Phase Colorimetric Sensor Based on Gold Nanoparticle-Loaded Polymer Brushes: Lead Detection as a Case Study |
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