BCR-ABL1 in leukemia: Disguise master outplays riding shotgun
Leukemia is a many-sided molecular disorder that arises because of over expression of oncogenes, suppression of tumor suppressor genes, and chromosomal translocations. These chromosomal rearrangements are nonetheless among the many determinants that underlie transformation of cells from normal to a...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2013-01, Vol.9 (1), p.6-10 |
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| container_title | Journal of cancer research and therapeutics |
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| creator | Rana, Aamir Ali, Ghulam Ali, Shaukat Khan, Ammara Mansoor, Sajid Malik, Shazia Farooqi, Ammad |
| description | Leukemia is a many-sided molecular disorder that arises because of over expression of oncogenes, suppression of tumor suppressor genes, and chromosomal translocations. These chromosomal rearrangements are nonetheless among the many determinants that underlie transformation of cells from normal to a cancerous phenotype and predispose cells to refractoriness against interventions by reduced drug influx and substantial drug efflux. This review unfolds current understanding of BCR-ABL1 (break point cluster region-c-abl oncogene 1, non-receptor tyrosine kinase) signaling with a focus on apoptotic suppressive mechanisms and alternative approaches to chronic myeloid leukemia therapy. |
| doi_str_mv | 10.4103/0973-1482.110339 |
| format | Article |
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| issn | 0973-1482 1998-4138 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Medknow Open Access Journals |
| subjects | Apoptosis Care and treatment Disease Progression Drug Resistance, Neoplasm - genetics Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Gene expression Genetic aspects Humans Kinases Leukemia Leukemia - drug therapy Leukemia - genetics Leukemia - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Mutation Proteins Risk factors Signal Transduction |
| title | BCR-ABL1 in leukemia: Disguise master outplays riding shotgun |
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