Microarray determination of Bcl-2 family protein inhibition sensitivity in breast cancer cells

This study tests the hypothesis that reverse transcription polymerase chain reaction (RT-PCR) microarrays can be used to predict the relative sensitivity to induction of apoptosis in breast cancer cells exposed to inhibitors of antiapoptotic Bcl-2 family proteins. Four cell lines, MDA-MB-231 (MDA-23...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2013-02, Vol.238 (2), p.248-256
Hauptverfasser:	Hudson, Sandra G, Halleran, Devin R, Nevaldine, Barbara, Shapiro, Anna, Hutchison, Robert E, Hahn, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Blotting, Western Breast Neoplasms - drug therapy Cell Line, Tumor Drug Screening Assays, Antitumor - methods Gamma Rays Humans Microarray Analysis - methods Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Pyrroles - pharmacology Reverse Transcriptase Polymerase Chain Reaction - methods
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