Multimodal Elucidation of Choline Metabolism in a Murine Glioma Model Using Magnetic Resonance Spectroscopy and 11C-Choline Positron Emission Tomography

The metabolites, transporters, and enzymes involved in choline metabolism are regarded as biomarkers for disease progression in a variety of cancers, but their in vivo detection is not ideal. Both magnetic resonance spectroscopy [MRS using chemical shift imaging (CSI) total choline (tCho)] and C-cho...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-03, Vol.73 (5), p.1470-1480
Hauptverfasser:	WEHRL, Hans F, SCHWAB, Julian, BUKALA, Daniel, HEEREN, Ron M. A, PICHLER, Bernd J, SAUTER, Alexander W, HASENBACH, Kathy, REISCHL, Gerald, TABATABAI, Ghazaleh, QUINTANILLA-MARTINEZ, Leticia, JIRU, Filip, CHUGHTAI, Kamila, KISS, Andras, CAY, Funda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Brain Neoplasms - diagnostic imaging Brain Neoplasms - pathology Disease Models, Animal Female Glioma - diagnostic imaging Glioma - pathology Magnetic Resonance Spectroscopy - methods Male Mass Spectrometry Medical sciences Mice Neurology Pharmacology. Drug treatments Positron-Emission Tomography - methods Tumors Tumors of the nervous system. Phacomatoses
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