Plasma drug concentrations and clinical effects of a peripheral alpha-2-adrenoceptor antagonist, MK-467, in horses sedated with detomidine

To investigate plasma drug concentrations and the effect of MK-467 (L-659′066) on sedation, heart rate and gut motility in horses sedated with intravenous (IV) detomidine. Experimental randomized blinded crossover study. Six healthy horses. Detomidine (10 μg kg−1 IV) was administered alone (DET) and...

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Veröffentlicht in:	Veterinary anaesthesia and analgesia 2013-05, Vol.40 (3), p.257-264
Hauptverfasser:	Vainionpää, Mari H, Raekallio, Marja R, Pakkanen, Soile AE, Ranta-Panula, Ville, Rinne, Valtteri M, Scheinin, Mika, Vainio, Outi M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Antagonists - blood Adrenergic alpha-2 Receptor Antagonists - pharmacokinetics Animals Area Under Curve bradycardia Conscious Sedation - veterinary Cross-Over Studies detomidine Drug Interactions Female Gastrointestinal Motility - drug effects gut motility Half-Life Heart Rate - drug effects horses Horses - blood Hypnotics and Sedatives Imidazoles - pharmacology MK-467 Quinolizines - blood Quinolizines - pharmacokinetics sedation
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