Determination of free desmosine in human plasma and its application in two experimental medicine studies

Elastin is one of the major extracellular matrix proteins associated with connective tissue. Its degradation leads to the liberation of the unique amino acids desmosine and isodesmosine. These have shown utility as biomarkers of elastin breakdown for disease progression, patient stratification, and...

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Veröffentlicht in:	Analytical biochemistry 2013-05, Vol.436 (2), p.127-136
Hauptverfasser:	Lamerz, Jens, Friedlein, Arno, Soder, Nicole, Cutler, Paul, Döbeli, Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged amino acids biomarkers Biomarkers - blood Body Mass Index Body mass index (BMI) Body Weight Case-Control Studies Chemical Precipitation Chromatography, High Pressure Liquid - methods Chronic obstructive pulmonary disease (COPD) Desmosine Desmosine - blood Deuterium disease course drugs elastin ethanol extracellular matrix Female high performance liquid chromatography Human plasma Humans Isodesmosine - blood Male mass spectrometry Mass Spectrometry - methods medicine Middle Aged monitoring patients Pulmonary Disease, Chronic Obstructive - blood Reference Values Reproducibility of Results Russia Selected reaction monitoring (SRM) Smoking United States
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