The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: An in vitro and in vivo study

Objective To examine the effect and underlying mechanism of action of the proteasome inhibitor lactacystin on glioma, in vitro and in vivo. Methods Rat C6 glioma cells were cultured with or without lactacystin. Cell proliferation, apoptosis and mitochondrial membrane potential were determined. A gli...

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Veröffentlicht in:	Journal of international medical research 2013-02, Vol.41 (1), p.72-81
Hauptverfasser:	Wang, Haifeng, Zhang, Shuyan, Zhong, Jiateng, Zhang, Jizhou, Luo, Yinan, Ge, Pengfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - pharmacology Acetylcysteine - therapeutic use Animals Apoptosis - drug effects Apoptosis - genetics bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biological and medical sciences Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Line, Tumor Cell Survival - drug effects Gene Expression Regulation, Neoplastic - drug effects General pharmacology Glioma - drug therapy Glioma - genetics Glioma - pathology Medical sciences Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred BALB C Mice, Nude Neurology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Proteasome Inhibitors - pharmacology Proteasome Inhibitors - therapeutic use Rats RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Burden - drug effects Tumors of the nervous system. Phacomatoses Xenograft Model Antitumor Assays
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