Plasminogen activator inhibitor-1 5G/5G genotype is associated with early spontaneous recanalization of the infarct-related artery in patients presenting with acute ST-elevation myocardial infarction
BACKGROUNDWe aimed to examine the association between plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism and early spontaneous recanalization in patients presenting with acute ST-elevation myocardial infarction. METHODSPatients admitted to our emergency department with ST-elevation myoca...
Gespeichert in:
| Veröffentlicht in: | Coronary artery disease 2013-05, Vol.24 (3), p.196-200 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 200 |
|---|---|
| container_issue | 3 |
| container_start_page | 196 |
| container_title | Coronary artery disease |
| container_volume | 24 |
| creator | Cagliyan, Caglar E Yuregir, Ozge O Balli, Mehmet Tekin, Kamuran Akilli, Rabia E Bozdogan, Sevcan T Turkmen, Serdar Deniz, Ali Baykan, Oytun A Aslan, Huseyin Cayli, Murat |
| description | BACKGROUNDWe aimed to examine the association between plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism and early spontaneous recanalization in patients presenting with acute ST-elevation myocardial infarction.
METHODSPatients admitted to our emergency department with ST-elevation myocardial infarction in the first 6 h of symptom onset were included. An immediate primary percutaneous coronary intervention was performed. Patients were grouped according to the initial patency of the infarct-related artery (IRA) as followstotal occlusion (TO) group [Thrombolysis in Myocardial Infarction (TIMI) 0–1 flow in the IRA], partial recanalization group (TIMI 2 flow in the IRA), and complete recanalization (CR) group (TIMI 3 flow in the IRA). PAI-1 4G/5G polymorphism was detected using the real-time PCR method.
RESULTSThere were 107 patients in the TO group, 30 patients in the partial recanalization group, and 45 patients in the CR group. When we evaluated degrees of patency according to the PAI-1 genotype, TO of the IRA was the highest in patients with the PAI 4G/4G genotype (PAI-1 4G/4G66.7%, PAI-1 4G/5G65.9%, PAI-1 5G/5G40.4%) and CR of the IRA was the highest in patients with the PAI 5G/5G genotype (PAI-1 5G/5G38.5%, PAI-1 4G/5G19.8%, PAI-1 4G/4G17.9%). The distribution of genotypes in different degrees of patency of IRA was statistically significant (P=0.029). In logistic regression analysis, the PAI-1 5G/5G genotype was associated independently with the spontaneous CR of the IRA (odds ratio2.875, 95% confidence interval [1.059–7.086], P=0.038).
CONCLUSIONPatients with the PAI-1 5G/5G genotype seem to be luckier than others in terms of early spontaneous recanalization of the IRA. Further prospective studies with large patient populations are required for more precise results. |
| doi_str_mv | 10.1097/MCA.0b013e32835d7633 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1325331000</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1325331000</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3524-42f4decc4a8a81a4d3d7a85cbfb1c14cf845c2fe7010f92e84b02fe491c7f1643</originalsourceid><addsrcrecordid>eNpdkcFu1DAQhiMEokvhDRDykUtaO7Y3ybFa0aVSEUiUczRxxo3Bawfb6Sq8IK9Vl7QgcbA8M57_G43_onjL6BmjbX3-aXdxRnvKOPKq4XKot5w_KzZM1LyUDafPiw1tpSi3bdWcFK9i_E4pE7KWL4uT6kFCOd0Uv79YiAfj_C06AiqZO0g-EONG05sclYzI_bnck_zu0zIhMZFAjF4ZSDiQo0kjQQh2IXHyLoFDP0cSUIEDa35BMt4Rr0kas9RpCCqVAe0fMYSEYcllMuU-dCmSKWDMgXG3KxrUnJB8vSnR4t0KOyxeQRgM2Cdgrr4uXmiwEd883qfFt8sPN7uP5fXn_dXu4rpUXFaiFJUWAyoloIGGgRj4UEMjVa97pphQuhFSVRpryqhuK2xET3MqWqZqzbaCnxbvV-4U_M8ZY-oOJiq0dl28Y7ySnDNKaW4Va6sKPsaAupuCOUBYOka7Bwu7bGH3v4VZ9u5xwtwfcPgrevLsH_fobf6_-MPORwzdiGDT2OXJrJWUlVXmUpnTMh8q-D3o4a2Z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1325331000</pqid></control><display><type>article</type><title>Plasminogen activator inhibitor-1 5G/5G genotype is associated with early spontaneous recanalization of the infarct-related artery in patients presenting with acute ST-elevation myocardial infarction</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Cagliyan, Caglar E ; Yuregir, Ozge O ; Balli, Mehmet ; Tekin, Kamuran ; Akilli, Rabia E ; Bozdogan, Sevcan T ; Turkmen, Serdar ; Deniz, Ali ; Baykan, Oytun A ; Aslan, Huseyin ; Cayli, Murat</creator><creatorcontrib>Cagliyan, Caglar E ; Yuregir, Ozge O ; Balli, Mehmet ; Tekin, Kamuran ; Akilli, Rabia E ; Bozdogan, Sevcan T ; Turkmen, Serdar ; Deniz, Ali ; Baykan, Oytun A ; Aslan, Huseyin ; Cayli, Murat</creatorcontrib><description>BACKGROUNDWe aimed to examine the association between plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism and early spontaneous recanalization in patients presenting with acute ST-elevation myocardial infarction.
METHODSPatients admitted to our emergency department with ST-elevation myocardial infarction in the first 6 h of symptom onset were included. An immediate primary percutaneous coronary intervention was performed. Patients were grouped according to the initial patency of the infarct-related artery (IRA) as followstotal occlusion (TO) group [Thrombolysis in Myocardial Infarction (TIMI) 0–1 flow in the IRA], partial recanalization group (TIMI 2 flow in the IRA), and complete recanalization (CR) group (TIMI 3 flow in the IRA). PAI-1 4G/5G polymorphism was detected using the real-time PCR method.
RESULTSThere were 107 patients in the TO group, 30 patients in the partial recanalization group, and 45 patients in the CR group. When we evaluated degrees of patency according to the PAI-1 genotype, TO of the IRA was the highest in patients with the PAI 4G/4G genotype (PAI-1 4G/4G66.7%, PAI-1 4G/5G65.9%, PAI-1 5G/5G40.4%) and CR of the IRA was the highest in patients with the PAI 5G/5G genotype (PAI-1 5G/5G38.5%, PAI-1 4G/5G19.8%, PAI-1 4G/4G17.9%). The distribution of genotypes in different degrees of patency of IRA was statistically significant (P=0.029). In logistic regression analysis, the PAI-1 5G/5G genotype was associated independently with the spontaneous CR of the IRA (odds ratio2.875, 95% confidence interval [1.059–7.086], P=0.038).
CONCLUSIONPatients with the PAI-1 5G/5G genotype seem to be luckier than others in terms of early spontaneous recanalization of the IRA. Further prospective studies with large patient populations are required for more precise results.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/MCA.0b013e32835d7633</identifier><identifier>PMID: 23283030</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Aged ; Chi-Square Distribution ; Coronary Angiography ; Coronary Occlusion - complications ; Coronary Occlusion - diagnostic imaging ; Coronary Occlusion - genetics ; Coronary Occlusion - physiopathology ; Coronary Occlusion - therapy ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - physiopathology ; Electrocardiography ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Logistic Models ; Male ; Middle Aged ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - genetics ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Odds Ratio ; Percutaneous Coronary Intervention ; Phenotype ; Plasminogen Activator Inhibitor 1 - genetics ; Polymorphism, Genetic ; Prognosis ; Real-Time Polymerase Chain Reaction ; Risk Factors ; Severity of Illness Index ; Vascular Patency - genetics</subject><ispartof>Coronary artery disease, 2013-05, Vol.24 (3), p.196-200</ispartof><rights>2013 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3524-42f4decc4a8a81a4d3d7a85cbfb1c14cf845c2fe7010f92e84b02fe491c7f1643</citedby><cites>FETCH-LOGICAL-c3524-42f4decc4a8a81a4d3d7a85cbfb1c14cf845c2fe7010f92e84b02fe491c7f1643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23283030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cagliyan, Caglar E</creatorcontrib><creatorcontrib>Yuregir, Ozge O</creatorcontrib><creatorcontrib>Balli, Mehmet</creatorcontrib><creatorcontrib>Tekin, Kamuran</creatorcontrib><creatorcontrib>Akilli, Rabia E</creatorcontrib><creatorcontrib>Bozdogan, Sevcan T</creatorcontrib><creatorcontrib>Turkmen, Serdar</creatorcontrib><creatorcontrib>Deniz, Ali</creatorcontrib><creatorcontrib>Baykan, Oytun A</creatorcontrib><creatorcontrib>Aslan, Huseyin</creatorcontrib><creatorcontrib>Cayli, Murat</creatorcontrib><title>Plasminogen activator inhibitor-1 5G/5G genotype is associated with early spontaneous recanalization of the infarct-related artery in patients presenting with acute ST-elevation myocardial infarction</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>BACKGROUNDWe aimed to examine the association between plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism and early spontaneous recanalization in patients presenting with acute ST-elevation myocardial infarction.
METHODSPatients admitted to our emergency department with ST-elevation myocardial infarction in the first 6 h of symptom onset were included. An immediate primary percutaneous coronary intervention was performed. Patients were grouped according to the initial patency of the infarct-related artery (IRA) as followstotal occlusion (TO) group [Thrombolysis in Myocardial Infarction (TIMI) 0–1 flow in the IRA], partial recanalization group (TIMI 2 flow in the IRA), and complete recanalization (CR) group (TIMI 3 flow in the IRA). PAI-1 4G/5G polymorphism was detected using the real-time PCR method.
RESULTSThere were 107 patients in the TO group, 30 patients in the partial recanalization group, and 45 patients in the CR group. When we evaluated degrees of patency according to the PAI-1 genotype, TO of the IRA was the highest in patients with the PAI 4G/4G genotype (PAI-1 4G/4G66.7%, PAI-1 4G/5G65.9%, PAI-1 5G/5G40.4%) and CR of the IRA was the highest in patients with the PAI 5G/5G genotype (PAI-1 5G/5G38.5%, PAI-1 4G/5G19.8%, PAI-1 4G/4G17.9%). The distribution of genotypes in different degrees of patency of IRA was statistically significant (P=0.029). In logistic regression analysis, the PAI-1 5G/5G genotype was associated independently with the spontaneous CR of the IRA (odds ratio2.875, 95% confidence interval [1.059–7.086], P=0.038).
CONCLUSIONPatients with the PAI-1 5G/5G genotype seem to be luckier than others in terms of early spontaneous recanalization of the IRA. Further prospective studies with large patient populations are required for more precise results.</description><subject>Adult</subject><subject>Aged</subject><subject>Chi-Square Distribution</subject><subject>Coronary Angiography</subject><subject>Coronary Occlusion - complications</subject><subject>Coronary Occlusion - diagnostic imaging</subject><subject>Coronary Occlusion - genetics</subject><subject>Coronary Occlusion - physiopathology</subject><subject>Coronary Occlusion - therapy</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - physiopathology</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - genetics</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Odds Ratio</subject><subject>Percutaneous Coronary Intervention</subject><subject>Phenotype</subject><subject>Plasminogen Activator Inhibitor 1 - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Vascular Patency - genetics</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFu1DAQhiMEokvhDRDykUtaO7Y3ybFa0aVSEUiUczRxxo3Bawfb6Sq8IK9Vl7QgcbA8M57_G43_onjL6BmjbX3-aXdxRnvKOPKq4XKot5w_KzZM1LyUDafPiw1tpSi3bdWcFK9i_E4pE7KWL4uT6kFCOd0Uv79YiAfj_C06AiqZO0g-EONG05sclYzI_bnck_zu0zIhMZFAjF4ZSDiQo0kjQQh2IXHyLoFDP0cSUIEDa35BMt4Rr0kas9RpCCqVAe0fMYSEYcllMuU-dCmSKWDMgXG3KxrUnJB8vSnR4t0KOyxeQRgM2Cdgrr4uXmiwEd883qfFt8sPN7uP5fXn_dXu4rpUXFaiFJUWAyoloIGGgRj4UEMjVa97pphQuhFSVRpryqhuK2xET3MqWqZqzbaCnxbvV-4U_M8ZY-oOJiq0dl28Y7ySnDNKaW4Va6sKPsaAupuCOUBYOka7Bwu7bGH3v4VZ9u5xwtwfcPgrevLsH_fobf6_-MPORwzdiGDT2OXJrJWUlVXmUpnTMh8q-D3o4a2Z</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Cagliyan, Caglar E</creator><creator>Yuregir, Ozge O</creator><creator>Balli, Mehmet</creator><creator>Tekin, Kamuran</creator><creator>Akilli, Rabia E</creator><creator>Bozdogan, Sevcan T</creator><creator>Turkmen, Serdar</creator><creator>Deniz, Ali</creator><creator>Baykan, Oytun A</creator><creator>Aslan, Huseyin</creator><creator>Cayli, Murat</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Plasminogen activator inhibitor-1 5G/5G genotype is associated with early spontaneous recanalization of the infarct-related artery in patients presenting with acute ST-elevation myocardial infarction</title><author>Cagliyan, Caglar E ; Yuregir, Ozge O ; Balli, Mehmet ; Tekin, Kamuran ; Akilli, Rabia E ; Bozdogan, Sevcan T ; Turkmen, Serdar ; Deniz, Ali ; Baykan, Oytun A ; Aslan, Huseyin ; Cayli, Murat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3524-42f4decc4a8a81a4d3d7a85cbfb1c14cf845c2fe7010f92e84b02fe491c7f1643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Chi-Square Distribution</topic><topic>Coronary Angiography</topic><topic>Coronary Occlusion - complications</topic><topic>Coronary Occlusion - diagnostic imaging</topic><topic>Coronary Occlusion - genetics</topic><topic>Coronary Occlusion - physiopathology</topic><topic>Coronary Occlusion - therapy</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - physiopathology</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - genetics</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>Odds Ratio</topic><topic>Percutaneous Coronary Intervention</topic><topic>Phenotype</topic><topic>Plasminogen Activator Inhibitor 1 - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Prognosis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Vascular Patency - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cagliyan, Caglar E</creatorcontrib><creatorcontrib>Yuregir, Ozge O</creatorcontrib><creatorcontrib>Balli, Mehmet</creatorcontrib><creatorcontrib>Tekin, Kamuran</creatorcontrib><creatorcontrib>Akilli, Rabia E</creatorcontrib><creatorcontrib>Bozdogan, Sevcan T</creatorcontrib><creatorcontrib>Turkmen, Serdar</creatorcontrib><creatorcontrib>Deniz, Ali</creatorcontrib><creatorcontrib>Baykan, Oytun A</creatorcontrib><creatorcontrib>Aslan, Huseyin</creatorcontrib><creatorcontrib>Cayli, Murat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cagliyan, Caglar E</au><au>Yuregir, Ozge O</au><au>Balli, Mehmet</au><au>Tekin, Kamuran</au><au>Akilli, Rabia E</au><au>Bozdogan, Sevcan T</au><au>Turkmen, Serdar</au><au>Deniz, Ali</au><au>Baykan, Oytun A</au><au>Aslan, Huseyin</au><au>Cayli, Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasminogen activator inhibitor-1 5G/5G genotype is associated with early spontaneous recanalization of the infarct-related artery in patients presenting with acute ST-elevation myocardial infarction</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2013-05</date><risdate>2013</risdate><volume>24</volume><issue>3</issue><spage>196</spage><epage>200</epage><pages>196-200</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>BACKGROUNDWe aimed to examine the association between plasminogen activator inhibitor-1 (PAI-1) genetic polymorphism and early spontaneous recanalization in patients presenting with acute ST-elevation myocardial infarction.
METHODSPatients admitted to our emergency department with ST-elevation myocardial infarction in the first 6 h of symptom onset were included. An immediate primary percutaneous coronary intervention was performed. Patients were grouped according to the initial patency of the infarct-related artery (IRA) as followstotal occlusion (TO) group [Thrombolysis in Myocardial Infarction (TIMI) 0–1 flow in the IRA], partial recanalization group (TIMI 2 flow in the IRA), and complete recanalization (CR) group (TIMI 3 flow in the IRA). PAI-1 4G/5G polymorphism was detected using the real-time PCR method.
RESULTSThere were 107 patients in the TO group, 30 patients in the partial recanalization group, and 45 patients in the CR group. When we evaluated degrees of patency according to the PAI-1 genotype, TO of the IRA was the highest in patients with the PAI 4G/4G genotype (PAI-1 4G/4G66.7%, PAI-1 4G/5G65.9%, PAI-1 5G/5G40.4%) and CR of the IRA was the highest in patients with the PAI 5G/5G genotype (PAI-1 5G/5G38.5%, PAI-1 4G/5G19.8%, PAI-1 4G/4G17.9%). The distribution of genotypes in different degrees of patency of IRA was statistically significant (P=0.029). In logistic regression analysis, the PAI-1 5G/5G genotype was associated independently with the spontaneous CR of the IRA (odds ratio2.875, 95% confidence interval [1.059–7.086], P=0.038).
CONCLUSIONPatients with the PAI-1 5G/5G genotype seem to be luckier than others in terms of early spontaneous recanalization of the IRA. Further prospective studies with large patient populations are required for more precise results.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>23283030</pmid><doi>10.1097/MCA.0b013e32835d7633</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-6928 |
| ispartof | Coronary artery disease, 2013-05, Vol.24 (3), p.196-200 |
| issn | 0954-6928 1473-5830 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1325331000 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Chi-Square Distribution Coronary Angiography Coronary Occlusion - complications Coronary Occlusion - diagnostic imaging Coronary Occlusion - genetics Coronary Occlusion - physiopathology Coronary Occlusion - therapy Coronary Vessels - diagnostic imaging Coronary Vessels - physiopathology Electrocardiography Female Gene Frequency Genetic Predisposition to Disease Humans Logistic Models Male Middle Aged Myocardial Infarction - diagnostic imaging Myocardial Infarction - genetics Myocardial Infarction - physiopathology Myocardial Infarction - therapy Odds Ratio Percutaneous Coronary Intervention Phenotype Plasminogen Activator Inhibitor 1 - genetics Polymorphism, Genetic Prognosis Real-Time Polymerase Chain Reaction Risk Factors Severity of Illness Index Vascular Patency - genetics |
| title | Plasminogen activator inhibitor-1 5G/5G genotype is associated with early spontaneous recanalization of the infarct-related artery in patients presenting with acute ST-elevation myocardial infarction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T17%3A50%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasminogen%20activator%20inhibitor-1%205G/5G%20genotype%20is%20associated%20with%20early%20spontaneous%20recanalization%20of%20the%20infarct-related%20artery%20in%20patients%20presenting%20with%20acute%20ST-elevation%20myocardial%20infarction&rft.jtitle=Coronary%20artery%20disease&rft.au=Cagliyan,%20Caglar%20E&rft.date=2013-05&rft.volume=24&rft.issue=3&rft.spage=196&rft.epage=200&rft.pages=196-200&rft.issn=0954-6928&rft.eissn=1473-5830&rft_id=info:doi/10.1097/MCA.0b013e32835d7633&rft_dat=%3Cproquest_cross%3E1325331000%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1325331000&rft_id=info:pmid/23283030&rfr_iscdi=true |