Ultrathin PEGylated W18O49 Nanowires as a New 980 nm-Laser-Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo

A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W18O49 nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 ± 0.5 °C upon irradiation with NIR laser light...

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Veröffentlicht in:	Advanced materials (Weinheim) 2013-04, Vol.25 (14), p.2095-2100
Hauptverfasser:	Chen, Zhigang, Wang, Qian, Wang, Huanli, Zhang, Lisha, Song, Guosheng, Song, Linlin, Hu, Junqing, Wang, Hongzhi, Liu, Jianshe, Zhu, Meifang, Zhao, Dongyuan
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Sprache:	eng
Schlagworte:	980 nm laser ablation Animals cancer cells HeLa Cells Humans Infrared Rays Mice Mice, SCID nanowires Nanowires - chemistry Nanowires - therapeutic use Nanowires - toxicity Neoplasms - therapy Oxides - chemistry photothermal agent Polyethylene Glycols - chemistry Surface Plasmon Resonance Temperature Transplantation, Heterologous Tungsten - chemistry W18O49
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container_end_page	2100
container_issue	14
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container_title	Advanced materials (Weinheim)
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creator	Chen, Zhigang Wang, Qian Wang, Huanli Zhang, Lisha Song, Guosheng Song, Linlin Hu, Junqing Wang, Hongzhi Liu, Jianshe Zhu, Meifang Zhao, Dongyuan
description	A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W18O49 nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 ± 0.5 °C upon irradiation with NIR laser light at a safe, low intensity (0.72 W cm−2) for 2 min (left‐hand mouse in the figure),), resulting in the efficient PTA of cancer cells in vivo in 10 min.
doi_str_mv	10.1002/adma.201204616
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Wang, Qian ; Wang, Huanli ; Zhang, Lisha ; Song, Guosheng ; Song, Linlin ; Hu, Junqing ; Wang, Hongzhi ; Liu, Jianshe ; Zhu, Meifang ; Zhao, Dongyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3656-3fb612e3bc710fd17ed8f7602ead53bd416b57ce220c284b8292a0a47727556d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>980 nm laser</topic><topic>ablation</topic><topic>Animals</topic><topic>cancer cells</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Infrared Rays</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>nanowires</topic><topic>Nanowires - chemistry</topic><topic>Nanowires - therapeutic use</topic><topic>Nanowires - toxicity</topic><topic>Neoplasms - therapy</topic><topic>Oxides - chemistry</topic><topic>photothermal agent</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Surface Plasmon Resonance</topic><topic>Temperature</topic><topic>Transplantation, Heterologous</topic><topic>Tungsten - chemistry</topic><topic>W18O49</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zhigang</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><creatorcontrib>Wang, Huanli</creatorcontrib><creatorcontrib>Zhang, Lisha</creatorcontrib><creatorcontrib>Song, Guosheng</creatorcontrib><creatorcontrib>Song, Linlin</creatorcontrib><creatorcontrib>Hu, Junqing</creatorcontrib><creatorcontrib>Wang, Hongzhi</creatorcontrib><creatorcontrib>Liu, Jianshe</creatorcontrib><creatorcontrib>Zhu, Meifang</creatorcontrib><creatorcontrib>Zhao, Dongyuan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zhigang</au><au>Wang, Qian</au><au>Wang, Huanli</au><au>Zhang, Lisha</au><au>Song, Guosheng</au><au>Song, Linlin</au><au>Hu, Junqing</au><au>Wang, Hongzhi</au><au>Liu, Jianshe</au><au>Zhu, Meifang</au><au>Zhao, Dongyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrathin PEGylated W18O49 Nanowires as a New 980 nm-Laser-Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv. Mater</addtitle><date>2013-04-11</date><risdate>2013</risdate><volume>25</volume><issue>14</issue><spage>2095</spage><epage>2100</epage><pages>2095-2100</pages><issn>0935-9648</issn><eissn>1521-4095</eissn><abstract>A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W18O49 nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 ± 0.5 °C upon irradiation with NIR laser light at a safe, low intensity (0.72 W cm−2) for 2 min (left‐hand mouse in the figure),), resulting in the efficient PTA of cancer cells in vivo in 10 min.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>23427112</pmid><doi>10.1002/adma.201204616</doi><tpages>6</tpages></addata></record>
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subjects	980 nm laser ablation Animals cancer cells HeLa Cells Humans Infrared Rays Mice Mice, SCID nanowires Nanowires - chemistry Nanowires - therapeutic use Nanowires - toxicity Neoplasms - therapy Oxides - chemistry photothermal agent Polyethylene Glycols - chemistry Surface Plasmon Resonance Temperature Transplantation, Heterologous Tungsten - chemistry W18O49
title	Ultrathin PEGylated W18O49 Nanowires as a New 980 nm-Laser-Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo
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