Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Boutique Science or Valuable Arrhythmia Model?

Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Boutique Science or Valuable Arrhythmia Model?

This article reviews the strengths and limitations of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) as models of cardiac arrhythmias. Specifically, the article attempts to answer the following questionsWhich clinical arrhythmias can be modeled by iPSC-CM? How well can iPSC-CM model...

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Veröffentlicht in:Circulation research 2013-03, Vol.112 (6), p.969-976
1. Verfasser: Knollmann, Björn C
Format: Artikel
Sprache:eng
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Arrhythmias, Cardiac - pathology
Humans
Induced Pluripotent Stem Cells - cytology
Myocytes, Cardiac - cytology
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description This article reviews the strengths and limitations of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) as models of cardiac arrhythmias. Specifically, the article attempts to answer the following questionsWhich clinical arrhythmias can be modeled by iPSC-CM? How well can iPSC-CM model adult ventricular myocytes? What are the strengths and limitations of published iPSC-CM arrhythmia models? What new mechanistic insight has been gained? What is the evidence that would support using iPSC-CM to personalize antiarrhythmic drug therapy? The review also discusses the pros and cons of using the iPSC-CM technology for modeling specific genetic arrhythmia disorders, such as long QT syndrome, Brugada Syndrome, or Catecholaminergic Polymorphic Ventricular Tachycardia.
doi_str_mv 10.1161/CIRCRESAHA.112.300567
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subjects Arrhythmias, Cardiac - pathology
Humans
Induced Pluripotent Stem Cells - cytology
Myocytes, Cardiac - cytology
title Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Boutique Science or Valuable Arrhythmia Model?
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