Influence of ezetimibe on ADMA-DDAH-NO pathway in rat liver subjected to partial ischemia followed by global reperfusion

We evaluated effect of ezetimibe on selected parameters determining NO level in rat liver subjected to ischemiareperfusion (IR). Rats received ezetimibe (5mg/kg) (groups E0 and EIR) or saline solution (groups C0 and CIR) intragastrically for 21 days. Then, the livers of CIR and EIR underwent ischemi...

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Veröffentlicht in:	Pharmacological reports 2013-01, Vol.65 (1), p.122-133
Hauptverfasser:	Trocha, Małgorzata, Merwid-Ląd, Anna, Sozański, Tomasz, Chlebda-Sieragowska, Ewa, Szuba, Andrzej, Dzięgiel, Piotr, Pieśniewska, Małgorzata, Fereniec-Gołębiewska, Lidia, Kwiatkowska, Joanna, Gomułkiewicz, Agnieszka, Cwynar-Zając, Łucja, Brykner, Renata, Szeląg, Adam
Format:	Artikel
Sprache:	eng
Schlagworte:	ADMA Amidohydrolases - metabolism Animals Anticholesteremic Agents - pharmacology Arginine - analogs & derivatives Arginine - metabolism Azetidines - pharmacology Drug Safety and Pharmacovigilance eNOS Ezetimibe ischemia/reperfusion liver Liver - drug effects Liver - pathology Male Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Pharmacotherapy Pharmacy rat Rats Rats, Wistar Real-Time Polymerase Chain Reaction Reperfusion Injury - drug therapy Reperfusion Injury - pathology RNA, Messenger - metabolism Time Factors
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