Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry

Context: Although primary aldosteronism (PA) is the most common cause of endocrine hypertension, histopathological methods to reveal the presence and sites of aldosterone overproduction remain to be established. Objective: The objective of the study was to investigate the significance of immunohisto...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2013-04, Vol.98 (4), p.1567-1574
Hauptverfasser:	Nanba, Kazutaka, Tsuiki, Mika, Sawai, Kuniko, Mukai, Kuniaki, Nishimoto, Koshiro, Usui, Takeshi, Tagami, Tetsuya, Okuno, Hiroshi, Yamamoto, Tetsuro, Shimatsu, Akira, Katabami, Takuyuki, Okumura, Ataru, Kawa, Gen, Tanabe, Akiyo, Naruse, Mitsuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma Adenoma - diagnosis Adenoma - metabolism Adenoma - pathology Adolescent Adrenal Cortex Neoplasms - diagnosis Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - pathology Adrenal Hyperplasia, Congenital - diagnosis Adrenal Hyperplasia, Congenital - genetics Adrenal Hyperplasia, Congenital - pathology Adrenalectomy Adult Aged Aldosterone Aldosterone - metabolism Aldosterone synthase Biomarkers - analysis Biomarkers - metabolism Child Computed tomography Cytochrome P-450 CYP11B2 - analysis Cytochrome P-450 CYP11B2 - metabolism Cytodiagnosis - methods Dexamethasone Diagnosis Female Humans Hyperaldosteronism - diagnosis Hyperaldosteronism - metabolism Hyperaldosteronism - pathology Hyperplasia Immunohistochemistry Male Middle Aged Staining and Labeling - methods Steroid 11β-hydroxylase Tumor Burden - physiology Tumors Young Adult
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