Initial Contact of Glioblastoma Cells with Existing Normal Brain Endothelial Cells Strengthen the Barrier Function via Fibroblast Growth Factor 2 Secretion: A New In Vitro Blood–Brain Barrier Model

Glioblastoma multiforme (GBM) cells invade along the existing normal capillaries in brain. Normal capillary endothelial cells function as the blood–brain barrier (BBB) that limits permeability of chemicals into the brain. To investigate whether GBM cells modulate the BBB function of normal endotheli...

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Veröffentlicht in:	Cellular and molecular neurobiology 2013-05, Vol.33 (4), p.489-501
Hauptverfasser:	Toyoda, Keisuke, Tanaka, Kunihiko, Nakagawa, Shinsuke, Thuy, Dinh Ha Duy, Ujifuku, Kenta, Kamada, Kensaku, Hayashi, Kentaro, Matsuo, Takayuki, Nagata, Izumi, Niwa, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Biology Cell Communication - drug effects Cell Line, Tumor Cell Membrane - drug effects Cell Membrane - metabolism Cell Movement - drug effects Culture Media, Conditioned - pharmacology Electric Impedance Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Fibroblast Growth Factor 2 - metabolism Glioblastoma - metabolism Glioblastoma - pathology Green Fluorescent Proteins - metabolism Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Models, Biological Neurobiology Neurosciences Original Research Rats Rats, Wistar Tight Junctions - drug effects Tight Junctions - metabolism Vascular Endothelial Growth Factor A - metabolism
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