Spectrofluorimetric determination of oseltamivir phosphate through derivatization with o-phthalaldehyde. Application to pharmaceutical preparations with a preliminary study on spiked plasma samples

ABSTRACT A simple and sensitive spectrofluorimetric method has been developed and validated for the determination of oseltamivir phosphate (OST) in pharmaceutical preparations. The method is based on the reaction between oseltamivir phosphate and o‐phthalaldehyde in presence of 2‐mercapto‐ethanol in...

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Veröffentlicht in:	Luminescence (Chichester, England) England), 2012-11, Vol.27 (6), p.511-518
Hauptverfasser:	Walash, M. I., Belal, F., El-Enany, N., El-Maghrabey, M. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Capsules - analysis Capsules - chemistry Fluorescence Humans Hydrogen-Ion Concentration Limit of Detection Mercaptoethanol - chemistry o-phthalaldehyde o-Phthalaldehyde - chemistry oseltamivir Oseltamivir - analysis Oseltamivir - blood Oseltamivir - chemistry pharmaceutical preparations Reproducibility of Results Sensitivity and Specificity Solvents spectrofluorimetry Spectrometry, Fluorescence - methods spiked human plasma Temperature
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