Upper esophageal sphincter and esophageal motility in patients with chronic cough and reflux: assessment by high-resolution manometry
Summary The pathophysiology of chronic cough and its association with dsymotility and laryngopharyngeal reflux remains unclear. This study applied high‐resolution manometry (HRM) to obtain a detailed evaluation of pharyngeal and esophageal motility in chronic cough patients with and without a positi...
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| Veröffentlicht in: | Diseases of the esophagus 2013-04, Vol.26 (3), p.219-225 |
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| creator | Vardar, R. Sweis, R. Anggiansah, A. Wong, T. Fox, M. R. |
| description | Summary
The pathophysiology of chronic cough and its association with dsymotility and laryngopharyngeal reflux remains unclear. This study applied high‐resolution manometry (HRM) to obtain a detailed evaluation of pharyngeal and esophageal motility in chronic cough patients with and without a positive reflux–cough symptom association probability (SAP). Retrospective analysis of 66 consecutive patients referred for investigation of chronic cough was performed. Thirty‐four (52%) were eligible for inclusion (age 55 [19–77], 62% female). HRM (ManoScan 360, Given/Sierra Scientific Instruments, Mountain View, CA) with 10 water swallows was performed followed by a 24‐hour ambulatory pH monitoring. Of this group, 21 (62%) patients had negative reflux–cough SAP (group A) and 13 (38%) had positive SAP (group B). Results from 23 healthy controls were available for comparison (group C). Detailed analysis revealed considerable heterogeneity. A small number of patients had pathological upper esophageal sphincter (UES) function (n = 9) or esophageal dysmotility (n = 1). The overall baseline UES pressure was similar, but average UES residual pressure was higher in groups A and B than in control group C (−0.2 and −0.8 mmHg vs. −5.4 mmHg; P |
| doi_str_mv | 10.1111/j.1442-2050.2012.01354.x |
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The pathophysiology of chronic cough and its association with dsymotility and laryngopharyngeal reflux remains unclear. This study applied high‐resolution manometry (HRM) to obtain a detailed evaluation of pharyngeal and esophageal motility in chronic cough patients with and without a positive reflux–cough symptom association probability (SAP). Retrospective analysis of 66 consecutive patients referred for investigation of chronic cough was performed. Thirty‐four (52%) were eligible for inclusion (age 55 [19–77], 62% female). HRM (ManoScan 360, Given/Sierra Scientific Instruments, Mountain View, CA) with 10 water swallows was performed followed by a 24‐hour ambulatory pH monitoring. Of this group, 21 (62%) patients had negative reflux–cough SAP (group A) and 13 (38%) had positive SAP (group B). Results from 23 healthy controls were available for comparison (group C). Detailed analysis revealed considerable heterogeneity. A small number of patients had pathological upper esophageal sphincter (UES) function (n = 9) or esophageal dysmotility (n = 1). The overall baseline UES pressure was similar, but average UES residual pressure was higher in groups A and B than in control group C (−0.2 and −0.8 mmHg vs. −5.4 mmHg; P < 0.018 and P < 0.005). The percentage of primary peristaltic contractions was lower in group B than in groups A and C (56% vs. 79% and 87%; P = 0.03 and P < 0.002). Additionally, intrabolus pressure at the lower esophageal sphincter was higher in group B than in group C (15.5 vs. 8.9; P = 0.024). HRM revealed changes to UES and esophageal motility in patients with chronic cough that are associated with impaired bolus clearance. These changes were most marked in group B patients with a positive reflux–cough symptom association.</description><identifier>ISSN: 1120-8694</identifier><identifier>EISSN: 1442-2050</identifier><identifier>DOI: 10.1111/j.1442-2050.2012.01354.x</identifier><identifier>PMID: 22591118</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Aged ; chronic cough ; Chronic Disease ; Cough - physiopathology ; Deglutition - physiology ; esophageal motility ; Esophageal Motility Disorders - physiopathology ; Esophageal pH Monitoring ; Esophageal Sphincter, Lower - physiopathology ; Esophageal Sphincter, Upper - physiopathology ; Female ; Gastrointestinal Motility - physiology ; high-resolution manometry (HRM) ; Humans ; laryngopharyngeal reflux (LPR) ; Laryngopharyngeal Reflux - physiopathology ; Male ; Manometry - methods ; Middle Aged ; Peristalsis - physiology ; pharyngeal motility ; Pharynx - physiopathology ; Pressure ; Retrospective Studies ; Time Factors ; Young Adult</subject><ispartof>Diseases of the esophagus, 2013-04, Vol.26 (3), p.219-225</ispartof><rights>2012 Copyright the Authors. Journal compilation © 2012, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus</rights><rights>2012 Copyright the Authors. Journal compilation © 2012, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4094-5b39767efc8997efe9f1efa9e64c0f5deccb55754c30ceeefa565e9ec28b9fa33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1442-2050.2012.01354.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1442-2050.2012.01354.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22591118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vardar, R.</creatorcontrib><creatorcontrib>Sweis, R.</creatorcontrib><creatorcontrib>Anggiansah, A.</creatorcontrib><creatorcontrib>Wong, T.</creatorcontrib><creatorcontrib>Fox, M. R.</creatorcontrib><title>Upper esophageal sphincter and esophageal motility in patients with chronic cough and reflux: assessment by high-resolution manometry</title><title>Diseases of the esophagus</title><addtitle>Dis Esophagus</addtitle><description>Summary
The pathophysiology of chronic cough and its association with dsymotility and laryngopharyngeal reflux remains unclear. This study applied high‐resolution manometry (HRM) to obtain a detailed evaluation of pharyngeal and esophageal motility in chronic cough patients with and without a positive reflux–cough symptom association probability (SAP). Retrospective analysis of 66 consecutive patients referred for investigation of chronic cough was performed. Thirty‐four (52%) were eligible for inclusion (age 55 [19–77], 62% female). HRM (ManoScan 360, Given/Sierra Scientific Instruments, Mountain View, CA) with 10 water swallows was performed followed by a 24‐hour ambulatory pH monitoring. Of this group, 21 (62%) patients had negative reflux–cough SAP (group A) and 13 (38%) had positive SAP (group B). Results from 23 healthy controls were available for comparison (group C). Detailed analysis revealed considerable heterogeneity. A small number of patients had pathological upper esophageal sphincter (UES) function (n = 9) or esophageal dysmotility (n = 1). The overall baseline UES pressure was similar, but average UES residual pressure was higher in groups A and B than in control group C (−0.2 and −0.8 mmHg vs. −5.4 mmHg; P < 0.018 and P < 0.005). The percentage of primary peristaltic contractions was lower in group B than in groups A and C (56% vs. 79% and 87%; P = 0.03 and P < 0.002). Additionally, intrabolus pressure at the lower esophageal sphincter was higher in group B than in group C (15.5 vs. 8.9; P = 0.024). HRM revealed changes to UES and esophageal motility in patients with chronic cough that are associated with impaired bolus clearance. These changes were most marked in group B patients with a positive reflux–cough symptom association.</description><subject>Adult</subject><subject>Aged</subject><subject>chronic cough</subject><subject>Chronic Disease</subject><subject>Cough - physiopathology</subject><subject>Deglutition - physiology</subject><subject>esophageal motility</subject><subject>Esophageal Motility Disorders - physiopathology</subject><subject>Esophageal pH Monitoring</subject><subject>Esophageal Sphincter, Lower - physiopathology</subject><subject>Esophageal Sphincter, Upper - physiopathology</subject><subject>Female</subject><subject>Gastrointestinal Motility - physiology</subject><subject>high-resolution manometry (HRM)</subject><subject>Humans</subject><subject>laryngopharyngeal reflux (LPR)</subject><subject>Laryngopharyngeal Reflux - physiopathology</subject><subject>Male</subject><subject>Manometry - methods</subject><subject>Middle Aged</subject><subject>Peristalsis - physiology</subject><subject>pharyngeal motility</subject><subject>Pharynx - physiopathology</subject><subject>Pressure</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1120-8694</issn><issn>1442-2050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkctu1DAUhi0EojdeAXnJJqmvScwCCfUyIJV206rsLMdzMvGQG7GjTh6g712nU0Z4c478__4W_hDClKQ0nvNtSoVgCSOSpIxQlhLKpUh379DxIXgfd8pIUmRKHKET77eE0JxnxUd0xJhUkVMco-eHYYARg--H2mzANNgPtetsiJemW_8ftH1wjQszdh0eTHDQBY-fXKixrce-cxbbftrUr89GqJpp9xUb78H7NlZxOePabepkjMhmCq7vcGu6voUwzmfoQ2UaD5_e5il6uL66v_iR3Nytfl58v0msIEoksuQqz3KobKFUHKAqCpVRkAlLKrkGa0spcyksJxYgRjKToMCyolSV4fwUfdlzh7H_O4EPunXeQtOYDvrJa8qZ4EWuMhqrn9-qU9nCWg-ja804639fFwvf9oUn18B8yCnRiyK91YsJvZjQiyL9qkjv9OXd_dWyRkCyBzgfYHcAmPGPznKeS_14u9K_fqvi9rpY6YK_ADYMmDk</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Vardar, R.</creator><creator>Sweis, R.</creator><creator>Anggiansah, A.</creator><creator>Wong, T.</creator><creator>Fox, M. R.</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Upper esophageal sphincter and esophageal motility in patients with chronic cough and reflux: assessment by high-resolution manometry</title><author>Vardar, R. ; Sweis, R. ; Anggiansah, A. ; Wong, T. ; Fox, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4094-5b39767efc8997efe9f1efa9e64c0f5deccb55754c30ceeefa565e9ec28b9fa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>chronic cough</topic><topic>Chronic Disease</topic><topic>Cough - physiopathology</topic><topic>Deglutition - physiology</topic><topic>esophageal motility</topic><topic>Esophageal Motility Disorders - physiopathology</topic><topic>Esophageal pH Monitoring</topic><topic>Esophageal Sphincter, Lower - physiopathology</topic><topic>Esophageal Sphincter, Upper - physiopathology</topic><topic>Female</topic><topic>Gastrointestinal Motility - physiology</topic><topic>high-resolution manometry (HRM)</topic><topic>Humans</topic><topic>laryngopharyngeal reflux (LPR)</topic><topic>Laryngopharyngeal Reflux - physiopathology</topic><topic>Male</topic><topic>Manometry - methods</topic><topic>Middle Aged</topic><topic>Peristalsis - physiology</topic><topic>pharyngeal motility</topic><topic>Pharynx - physiopathology</topic><topic>Pressure</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vardar, R.</creatorcontrib><creatorcontrib>Sweis, R.</creatorcontrib><creatorcontrib>Anggiansah, A.</creatorcontrib><creatorcontrib>Wong, T.</creatorcontrib><creatorcontrib>Fox, M. R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Diseases of the esophagus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vardar, R.</au><au>Sweis, R.</au><au>Anggiansah, A.</au><au>Wong, T.</au><au>Fox, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upper esophageal sphincter and esophageal motility in patients with chronic cough and reflux: assessment by high-resolution manometry</atitle><jtitle>Diseases of the esophagus</jtitle><addtitle>Dis Esophagus</addtitle><date>2013-04</date><risdate>2013</risdate><volume>26</volume><issue>3</issue><spage>219</spage><epage>225</epage><pages>219-225</pages><issn>1120-8694</issn><eissn>1442-2050</eissn><abstract>Summary
The pathophysiology of chronic cough and its association with dsymotility and laryngopharyngeal reflux remains unclear. This study applied high‐resolution manometry (HRM) to obtain a detailed evaluation of pharyngeal and esophageal motility in chronic cough patients with and without a positive reflux–cough symptom association probability (SAP). Retrospective analysis of 66 consecutive patients referred for investigation of chronic cough was performed. Thirty‐four (52%) were eligible for inclusion (age 55 [19–77], 62% female). HRM (ManoScan 360, Given/Sierra Scientific Instruments, Mountain View, CA) with 10 water swallows was performed followed by a 24‐hour ambulatory pH monitoring. Of this group, 21 (62%) patients had negative reflux–cough SAP (group A) and 13 (38%) had positive SAP (group B). Results from 23 healthy controls were available for comparison (group C). Detailed analysis revealed considerable heterogeneity. A small number of patients had pathological upper esophageal sphincter (UES) function (n = 9) or esophageal dysmotility (n = 1). The overall baseline UES pressure was similar, but average UES residual pressure was higher in groups A and B than in control group C (−0.2 and −0.8 mmHg vs. −5.4 mmHg; P < 0.018 and P < 0.005). The percentage of primary peristaltic contractions was lower in group B than in groups A and C (56% vs. 79% and 87%; P = 0.03 and P < 0.002). Additionally, intrabolus pressure at the lower esophageal sphincter was higher in group B than in group C (15.5 vs. 8.9; P = 0.024). HRM revealed changes to UES and esophageal motility in patients with chronic cough that are associated with impaired bolus clearance. These changes were most marked in group B patients with a positive reflux–cough symptom association.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>22591118</pmid><doi>10.1111/j.1442-2050.2012.01354.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diseases of the esophagus, 2013-04, Vol.26 (3), p.219-225 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged chronic cough Chronic Disease Cough - physiopathology Deglutition - physiology esophageal motility Esophageal Motility Disorders - physiopathology Esophageal pH Monitoring Esophageal Sphincter, Lower - physiopathology Esophageal Sphincter, Upper - physiopathology Female Gastrointestinal Motility - physiology high-resolution manometry (HRM) Humans laryngopharyngeal reflux (LPR) Laryngopharyngeal Reflux - physiopathology Male Manometry - methods Middle Aged Peristalsis - physiology pharyngeal motility Pharynx - physiopathology Pressure Retrospective Studies Time Factors Young Adult |
| title | Upper esophageal sphincter and esophageal motility in patients with chronic cough and reflux: assessment by high-resolution manometry |
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