Gamma-Aminobutyric Acid Binds to GABAB Receptor to Inhibit Cholangiocarcinoma Cells Growth via the JAK/STAT3 Pathway

Background Gamma-aminobutyric acid (GABA) has been reported to inhibit the growth of cholangiocarcinoma QBC939 cells, but the mechanisms are still not fully understood. Aims To explore the mechanisms of the anti-cancer effect of GABA on QBC939 cells. Methods An initial immunohistochemistry study of...

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Veröffentlicht in:	Digestive diseases and sciences 2013-03, Vol.58 (3), p.734-743
Hauptverfasser:	Huang, Qiang, Zhu, Cheng-lin, Liu, Chen-hai, Xie, Fang, Zhu, Kai, Hu, San-yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Cell Line, Tumor Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology gamma-Aminobutyric Acid - metabolism Gastroenterology Gene Expression Regulation, Neoplastic Hepatology Humans Janus Kinases - genetics Janus Kinases - metabolism Medicine Medicine & Public Health Mice Mice, Nude Neoplasms, Experimental - metabolism Oncology Original Article Protein Binding Receptors, GABA-B - genetics Receptors, GABA-B - metabolism STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Transplant Surgery
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