Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice. e1003207

Prader-Willi Syndrome is the most common syndromic form of human obesity and is caused by the loss of function of several genes, including MAGEL2. Mice lacking Magel2 display increased weight gain with excess adiposity and other defects suggestive of hypothalamic deficiency. We demonstrate Magel2-nu...

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Veröffentlicht in:	PLoS genetics 2013-01, Vol.9 (1)
Hauptverfasser:	Mercer, Rebecca E, Michaelson, Sheldon D, Chee, Melissa JS, Atallah, Tanya A, Wevrick, Rachel, Colmers, William F
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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