Effective humoral immunity against diphtheria and tetanus in patients with systemic lupus erythematosus or myasthenia gravis
► Diphtheria-antitoxin IgG levels do not differ between controls and SLE patients. ► Tetanus-antitoxoid IgG levels do not differ between controls and SLE or MG patients. ► Severity of SLE or MG does not influence the vaccine-induced immune response. ► First study on humoral immunity against diphther...
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| Veröffentlicht in: | Molecular immunology 2013-07, Vol.54 (3-4), p.453-456 |
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| container_title | Molecular immunology |
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| creator | Csuka, Dorottya Czirják, László Hóbor, Renáta Illes, Zsolt Bánáti, Miklós Rajczy, Katalin Tordai, Attila Füst, George |
| description | ► Diphtheria-antitoxin IgG levels do not differ between controls and SLE patients. ► Tetanus-antitoxoid IgG levels do not differ between controls and SLE or MG patients. ► Severity of SLE or MG does not influence the vaccine-induced immune response. ► First study on humoral immunity against diphtheria and tetanus in MG patients.
Controversy exists about the effectiveness of vaccine-induced immune response in patients with immunoregulatory disorders. Our aim was to determine the antibody titers to diphtheria and tetanus in patients with either of two autoimmune diseases.
279 patients with SLE (205 females, aged 45.0±13.8 years), 158 patients with myasthenia gravis (MG) (101 females, aged 55±18.7 years) and 208 healthy subjects (122 females, aged 48±14.6 years) were enrolled. Serum concentrations of diphtheria-antitoxin-IgG (A-DIPHTH) and tetanus-antitoxoid-IgG (A-TET) were determined with ELISA.
Equal proportions of healthy subjects, as well as patients with SLE or MG exhibited proper antibody responses and immune protection against diphtheria and tetanus. In all three test groups, serum concentration of A-DIPHTH decreased significantly (p60-years-old) subjects. There were no significant differences among the groups in the age-related changes of A-TET and A-DIPHTH except that in |
| doi_str_mv | 10.1016/j.molimm.2013.01.012 |
| format | Article |
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Controversy exists about the effectiveness of vaccine-induced immune response in patients with immunoregulatory disorders. Our aim was to determine the antibody titers to diphtheria and tetanus in patients with either of two autoimmune diseases.
279 patients with SLE (205 females, aged 45.0±13.8 years), 158 patients with myasthenia gravis (MG) (101 females, aged 55±18.7 years) and 208 healthy subjects (122 females, aged 48±14.6 years) were enrolled. Serum concentrations of diphtheria-antitoxin-IgG (A-DIPHTH) and tetanus-antitoxoid-IgG (A-TET) were determined with ELISA.
Equal proportions of healthy subjects, as well as patients with SLE or MG exhibited proper antibody responses and immune protection against diphtheria and tetanus. In all three test groups, serum concentration of A-DIPHTH decreased significantly (p<0.001) with age throughout the study population, while titers of A-TET dropped only in the elderly (>60-years-old) subjects. There were no significant differences among the groups in the age-related changes of A-TET and A-DIPHTH except that in <40-years-old subjects, A-DIPHTH level was significantly (p=0.029) lower in SLE patients than in controls.
Our findings suggest that the level of vaccine-induced immunity against diphtheria and tetanus infections in patients with SLE or MG is comparable to the healthy population.</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/j.molimm.2013.01.012</identifier><identifier>PMID: 23454161</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Antibodies, Bacterial - immunology ; Antibody Formation - immunology ; Case-Control Studies ; Diphtheria ; Diphtheria - complications ; Diphtheria - immunology ; Diphtheria Antitoxin - immunology ; Diphtheria Toxoid - immunology ; Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage ; Diphtheria-Tetanus-Pertussis Vaccine - immunology ; Female ; Humans ; Immunity, Humoral - immunology ; Immunoglobulin G - immunology ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - microbiology ; Male ; Middle Aged ; Myasthenia gravis ; Myasthenia Gravis - immunology ; Myasthenia Gravis - microbiology ; Systemic lupus erythematosus ; Tetanus ; Tetanus - complications ; Tetanus - immunology ; Tetanus Toxoid - immunology ; Vaccine-induced immune response</subject><ispartof>Molecular immunology, 2013-07, Vol.54 (3-4), p.453-456</ispartof><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-c49c7b0a8250f3cf8d2bc4a5e41da4876a77b91c7c4c90ee78d4d72ce77955fe3</citedby><cites>FETCH-LOGICAL-c395t-c49c7b0a8250f3cf8d2bc4a5e41da4876a77b91c7c4c90ee78d4d72ce77955fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0161589013000321$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23454161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Csuka, Dorottya</creatorcontrib><creatorcontrib>Czirják, László</creatorcontrib><creatorcontrib>Hóbor, Renáta</creatorcontrib><creatorcontrib>Illes, Zsolt</creatorcontrib><creatorcontrib>Bánáti, Miklós</creatorcontrib><creatorcontrib>Rajczy, Katalin</creatorcontrib><creatorcontrib>Tordai, Attila</creatorcontrib><creatorcontrib>Füst, George</creatorcontrib><title>Effective humoral immunity against diphtheria and tetanus in patients with systemic lupus erythematosus or myasthenia gravis</title><title>Molecular immunology</title><addtitle>Mol Immunol</addtitle><description>► Diphtheria-antitoxin IgG levels do not differ between controls and SLE patients. ► Tetanus-antitoxoid IgG levels do not differ between controls and SLE or MG patients. ► Severity of SLE or MG does not influence the vaccine-induced immune response. ► First study on humoral immunity against diphtheria and tetanus in MG patients.
Controversy exists about the effectiveness of vaccine-induced immune response in patients with immunoregulatory disorders. Our aim was to determine the antibody titers to diphtheria and tetanus in patients with either of two autoimmune diseases.
279 patients with SLE (205 females, aged 45.0±13.8 years), 158 patients with myasthenia gravis (MG) (101 females, aged 55±18.7 years) and 208 healthy subjects (122 females, aged 48±14.6 years) were enrolled. Serum concentrations of diphtheria-antitoxin-IgG (A-DIPHTH) and tetanus-antitoxoid-IgG (A-TET) were determined with ELISA.
Equal proportions of healthy subjects, as well as patients with SLE or MG exhibited proper antibody responses and immune protection against diphtheria and tetanus. In all three test groups, serum concentration of A-DIPHTH decreased significantly (p<0.001) with age throughout the study population, while titers of A-TET dropped only in the elderly (>60-years-old) subjects. There were no significant differences among the groups in the age-related changes of A-TET and A-DIPHTH except that in <40-years-old subjects, A-DIPHTH level was significantly (p=0.029) lower in SLE patients than in controls.
Our findings suggest that the level of vaccine-induced immunity against diphtheria and tetanus infections in patients with SLE or MG is comparable to the healthy population.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antibody Formation - immunology</subject><subject>Case-Control Studies</subject><subject>Diphtheria</subject><subject>Diphtheria - complications</subject><subject>Diphtheria - immunology</subject><subject>Diphtheria Antitoxin - immunology</subject><subject>Diphtheria Toxoid - immunology</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Humoral - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Erythematosus, Systemic - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - immunology</subject><subject>Myasthenia Gravis - microbiology</subject><subject>Systemic lupus erythematosus</subject><subject>Tetanus</subject><subject>Tetanus - complications</subject><subject>Tetanus - immunology</subject><subject>Tetanus Toxoid - immunology</subject><subject>Vaccine-induced immune response</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFr3DAQhUVJaTZp_0EpOubirSRLln0plJA2gUAv7VlopXFWi2W7GnmDoT--Cpv0GAoDQjPfewPzCPnI2ZYz3nw-bOM0hBi3gvF6y3gp8YZseKtF1XEpzsimYLxSbcfOyQXigTHWsEa9I-eilkqW4Yb8uel7cDkcge6XOCU70OK5jCGv1D7YMGKmPsz7vIcULLWjpxmyHRekYaSzzQHGjPQx5D3FFTPE4OiwzGUOaS2qaPOE5TclGleLpTMWn4dkjwHfk7e9HRA-PL-X5Ne3m5_Xt9X9j-9311_vK1d3KldOdk7vmG2FYn3t-taLnZNWgeTeylY3Vutdx5120nUMQLdeei0caN0p1UN9Sa5OvnOafi-A2cSADobBjjAtaHgt6pZLpuv_QLlulWK6Kag8oS5NiAl6M6cQbVoNZ-YpInMwp4jMU0SG8VKiyD49b1h2Efw_0UsmBfhyAqCc5BggGXTlyg58SCUq46fw-oa_-jenwg</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Csuka, Dorottya</creator><creator>Czirják, László</creator><creator>Hóbor, Renáta</creator><creator>Illes, Zsolt</creator><creator>Bánáti, Miklós</creator><creator>Rajczy, Katalin</creator><creator>Tordai, Attila</creator><creator>Füst, George</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T5</scope><scope>7TK</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>201307</creationdate><title>Effective humoral immunity against diphtheria and tetanus in patients with systemic lupus erythematosus or myasthenia gravis</title><author>Csuka, Dorottya ; 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Controversy exists about the effectiveness of vaccine-induced immune response in patients with immunoregulatory disorders. Our aim was to determine the antibody titers to diphtheria and tetanus in patients with either of two autoimmune diseases.
279 patients with SLE (205 females, aged 45.0±13.8 years), 158 patients with myasthenia gravis (MG) (101 females, aged 55±18.7 years) and 208 healthy subjects (122 females, aged 48±14.6 years) were enrolled. Serum concentrations of diphtheria-antitoxin-IgG (A-DIPHTH) and tetanus-antitoxoid-IgG (A-TET) were determined with ELISA.
Equal proportions of healthy subjects, as well as patients with SLE or MG exhibited proper antibody responses and immune protection against diphtheria and tetanus. In all three test groups, serum concentration of A-DIPHTH decreased significantly (p<0.001) with age throughout the study population, while titers of A-TET dropped only in the elderly (>60-years-old) subjects. There were no significant differences among the groups in the age-related changes of A-TET and A-DIPHTH except that in <40-years-old subjects, A-DIPHTH level was significantly (p=0.029) lower in SLE patients than in controls.
Our findings suggest that the level of vaccine-induced immunity against diphtheria and tetanus infections in patients with SLE or MG is comparable to the healthy population.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23454161</pmid><doi>10.1016/j.molimm.2013.01.012</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-5890 |
| ispartof | Molecular immunology, 2013-07, Vol.54 (3-4), p.453-456 |
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| language | eng |
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| subjects | Adult Aged Antibodies, Bacterial - immunology Antibody Formation - immunology Case-Control Studies Diphtheria Diphtheria - complications Diphtheria - immunology Diphtheria Antitoxin - immunology Diphtheria Toxoid - immunology Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage Diphtheria-Tetanus-Pertussis Vaccine - immunology Female Humans Immunity, Humoral - immunology Immunoglobulin G - immunology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - microbiology Male Middle Aged Myasthenia gravis Myasthenia Gravis - immunology Myasthenia Gravis - microbiology Systemic lupus erythematosus Tetanus Tetanus - complications Tetanus - immunology Tetanus Toxoid - immunology Vaccine-induced immune response |
| title | Effective humoral immunity against diphtheria and tetanus in patients with systemic lupus erythematosus or myasthenia gravis |
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