Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood

Background The generation and maintenance of allergen-specific T-cell tolerance is a key step in healthy immune responses to allergens and successful allergen-specific immunotherapy. Breaking of peripheral T-cell tolerance to allergens can lead to the development of allergies, but the mechanisms are...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2013-03, Vol.131 (3), p.875-885.e9
Hauptverfasser:	Kücüksezer, Umut Can, PhD, Palomares, Oscar, PhD, Rückert, Beate, Jartti, Tuomas, MD, Puhakka, Tuomo, MD, Nandy, Andreas, PhD, Gemicioğlu, Bilun, MD, PhD, Fahrner, Heinz B., MD, Jung, Andreas, MD, Deniz, Günnur, PhD, Akdis, Cezmi A., MD, Akdis, Mübeccel, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptor proteins allergen-specific T cells Allergens Allergens - immunology Allergic diseases Allergies Allergy and Immunology Antigens, Plant - immunology Atopy Biological and medical sciences CD4 antigen CD4-Positive T-Lymphocytes Cell growth Cells, Cultured Cytokines Cytokines - genetics Cytokines - immunology Dendritic cells Dendritic Cells - immunology Differentiation Esters Experiments Flow cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression Helper cells Human subjects Humans Hypersensitivity Hypersensitivity - blood Hypersensitivity - diagnosis Hypersensitivity - immunology IL-1β IL-6 Immune response Immune system Immune Tolerance Immunoglobulin E - blood Immunoglobulin G - blood Immunological tolerance Immunopathology Immunotherapy Inflammation Interleukin 10 Interleukin 13 Interleukin 17 Interleukin 6 Leukocytes, Mononuclear - immunology Lymphocytes T Medical sciences Molecular modelling myeloid dendritic cells Palatine Tonsil - immunology Peptides Peripheral blood Peripheral tolerance Plant Proteins - immunology Polymerase chain reaction proinflammatory cytokines RNA, Messenger - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Software T-Lymphocytes - immunology Throat surgery TLR7 protein TLR9 protein Toll-like receptors Toll-Like Receptors - immunology Tonsil tonsils Transcription factors
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