Value of IL28B genotyping in patients with HCV-related mixed cryoglobulinemia: results of a large, prospective study

Summary HCV‐related mixed cryoglobulinemia (MC) is characterized by clonal expansion of B cells producing a polyreactive natural antibody (rheumatoid factor) and interferon (IFN)‐based therapy is the first therapeutic option in mild‐moderate MC. Single nucleotide polymorphisms (SNPs) proximal to gen...

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Veröffentlicht in:	Journal of viral hepatitis 2013-04, Vol.20 (4), p.e107-e114
Hauptverfasser:	Piluso, A., Giannini, C., Fognani, E., Gragnani, L., Caini, P., Monti, M., Petrarca, A., Ranieri, J., Urraro, T., Triboli, E., Laffi, G., Zignego, A. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Cryoglobulinemia - genetics Female Genotype Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Humans interferon-based antiviral treatment Interferons - therapeutic use interleukin 28B Interleukins - genetics Male Middle Aged mixed cryoglobulinemia Polymorphism, Single Nucleotide Real-Time Polymerase Chain Reaction Sequence Analysis, DNA Treatment Outcome
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