Ultrasound contrast agents
Microbubbles, developed as ultrasound contrast agents for vascular imaging are valuable theranostic agents for multiple biomedical applications. The utility of these agents can be attributed to their unique response to ultrasound. When exposed to an acoustic pulse, microbubbles can resonate to creat...
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| Veröffentlicht in: | Journal of drug delivery science and technology 2013, Vol.23 (1), p.57-72 |
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| container_title | Journal of drug delivery science and technology |
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| creator | Wheatley, M.A. Cochran, M. |
| description | Microbubbles, developed as ultrasound contrast agents for vascular imaging are valuable theranostic agents for multiple biomedical applications. The utility of these agents can be attributed to their unique response to ultrasound. When exposed to an acoustic pulse, microbubbles can resonate to create a strong acoustic signal that can be used to diagnose conditions including cardiac abnormalities and cancerous lesions. Microbubble resonance can also generate powerful and localized forces capable of creating pores in cell membranes and blood vessels that can be used for targeted drug and gene delivery as well as thromoblysis and opening of the blood brain barrier. Microbubbles have been encapsulated with a variety of materials including lipids, proteins and polymers, these materials have been shown to control a microbubble's acoustic properties as well as its effectiveness as a drug carrier. This review focuses on the progress of microbubbles and the applications of microbubbles as theragnostic agents. |
| doi_str_mv | 10.1016/S1773-2247(13)50007-4 |
| format | Article |
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The utility of these agents can be attributed to their unique response to ultrasound. When exposed to an acoustic pulse, microbubbles can resonate to create a strong acoustic signal that can be used to diagnose conditions including cardiac abnormalities and cancerous lesions. Microbubble resonance can also generate powerful and localized forces capable of creating pores in cell membranes and blood vessels that can be used for targeted drug and gene delivery as well as thromoblysis and opening of the blood brain barrier. Microbubbles have been encapsulated with a variety of materials including lipids, proteins and polymers, these materials have been shown to control a microbubble's acoustic properties as well as its effectiveness as a drug carrier. 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This review focuses on the progress of microbubbles and the applications of microbubbles as theragnostic agents.</description><subject>Acoustics</subject><subject>Blood vessels</subject><subject>Blood-brain barrier</subject><subject>Cell membranes</subject><subject>Contrast media</subject><subject>Drug and gene delivery</subject><subject>Drug delivery</subject><subject>Gene transfer</subject><subject>Heart</subject><subject>Imaging</subject><subject>Lipids</subject><subject>Molecular imaging</subject><subject>Neuroimaging</subject><subject>Pores</subject><subject>Theranostics</subject><subject>Ultrasound</subject><subject>Ultrasound contrast agent</subject><issn>1773-2247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLAzEUhbNQsNT-AUHosi5Gc_OcrESKLyi40K5DJnNHRqaTmmQE_70zrbh1dS-Hcw6cj5BLoNdAQd28gta8YEzoFfArSSnVhTghsz_5jCxS-hh10BQEMzNyse1ydCkMfb30oZ_-vHTv2Od0Tk4b1yVc_N452T7cv62fis3L4_P6blN4bkQuQEp0tWqkAFBGoeBON9wrwZSQ3FcMJRqunNGuKishFTZlSSsUILipmOdzsjr27mP4HDBlu2uTx65zPYYhWeCMl0BLpkerPFp9DClFbOw-tjsXvy1QOyGwBwR22jrm7AGBFWPu9pjDccdXi9Em32LvsW4j-mzr0P7T8AN4_WLT</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Wheatley, M.A.</creator><creator>Cochran, M.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2013</creationdate><title>Ultrasound contrast agents</title><author>Wheatley, M.A. ; Cochran, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-155ead6f5411696e43a7f3c6426453cb2e5e936a97ab8b456ef880be41439b2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acoustics</topic><topic>Blood vessels</topic><topic>Blood-brain barrier</topic><topic>Cell membranes</topic><topic>Contrast media</topic><topic>Drug and gene delivery</topic><topic>Drug delivery</topic><topic>Gene transfer</topic><topic>Heart</topic><topic>Imaging</topic><topic>Lipids</topic><topic>Molecular imaging</topic><topic>Neuroimaging</topic><topic>Pores</topic><topic>Theranostics</topic><topic>Ultrasound</topic><topic>Ultrasound contrast agent</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wheatley, M.A.</creatorcontrib><creatorcontrib>Cochran, M.</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of drug delivery science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wheatley, M.A.</au><au>Cochran, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasound contrast agents</atitle><jtitle>Journal of drug delivery science and technology</jtitle><date>2013</date><risdate>2013</risdate><volume>23</volume><issue>1</issue><spage>57</spage><epage>72</epage><pages>57-72</pages><issn>1773-2247</issn><abstract>Microbubbles, developed as ultrasound contrast agents for vascular imaging are valuable theranostic agents for multiple biomedical applications. 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| ispartof | Journal of drug delivery science and technology, 2013, Vol.23 (1), p.57-72 |
| issn | 1773-2247 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Acoustics Blood vessels Blood-brain barrier Cell membranes Contrast media Drug and gene delivery Drug delivery Gene transfer Heart Imaging Lipids Molecular imaging Neuroimaging Pores Theranostics Ultrasound Ultrasound contrast agent |
| title | Ultrasound contrast agents |
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