Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood
The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high‐performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and pali...
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| Veröffentlicht in: | Journal of forensic sciences 2013-01, Vol.58 (1), p.90-100 |
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| container_title | Journal of forensic sciences |
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| creator | Butzbach, Danielle M. Stockham, Peter C. Kobus, Hilton J. Noel Sims, D. Byard, Roger W. Lokan, Robert J. Stewart Walker, George |
| description | The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high‐performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37°C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7°C, but degraded significantly in inoculated blood at 20 and 37°C. Complete loss occurred within 2 days when incubated at 37°C. The benzisoxazole‐cleaved degradation products for both drugs were identified as 2‐hydroxybenzoyl‐risperidone and 2‐hydroxybenzoyl‐paliperidone utilizing liquid chromatography quadrupole‐time‐of‐flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ. |
| doi_str_mv | 10.1111/j.1556-4029.2012.02280.x |
| format | Article |
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Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37°C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7°C, but degraded significantly in inoculated blood at 20 and 37°C. Complete loss occurred within 2 days when incubated at 37°C. The benzisoxazole‐cleaved degradation products for both drugs were identified as 2‐hydroxybenzoyl‐risperidone and 2‐hydroxybenzoyl‐paliperidone utilizing liquid chromatography quadrupole‐time‐of‐flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ.</description><identifier>ISSN: 0022-1198</identifier><identifier>EISSN: 1556-4029</identifier><identifier>DOI: 10.1111/j.1556-4029.2012.02280.x</identifier><identifier>PMID: 22994980</identifier><identifier>CODEN: JFSCAS</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>2-hydroxybenzoyl-paliperidone ; 2-hydroxybenzoyl-risperidone ; Animals ; Antipsychotic Agents - blood ; Bacteria ; Blood ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Drug Stability ; Drugs ; forensic science ; Forensic sciences ; Forensic Toxicology ; Gram-Positive Bacteria - metabolism ; Isoxazoles - blood ; Mass spectrometry ; paliperidone ; Paliperidone Palmitate ; Postmortem Changes ; putrefaction ; Pyrimidines - blood ; risperidone ; Risperidone - analogs & derivatives ; Risperidone - blood ; Specimen Handling ; Spectrometry, Mass, Electrospray Ionization ; Swine ; Temperature</subject><ispartof>Journal of forensic sciences, 2013-01, Vol.58 (1), p.90-100</ispartof><rights>2012 American Academy of Forensic Sciences</rights><rights>2012 American Academy of Forensic Sciences.</rights><rights>Copyright American Society for Testing and Materials Jan 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4680-2dab33d4a755f30b53b1c72dd89c8bf9b18ea0c5ae927cde0a78819c7d2fe4c73</citedby><cites>FETCH-LOGICAL-c4680-2dab33d4a755f30b53b1c72dd89c8bf9b18ea0c5ae927cde0a78819c7d2fe4c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1556-4029.2012.02280.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1556-4029.2012.02280.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22994980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butzbach, Danielle M.</creatorcontrib><creatorcontrib>Stockham, Peter C.</creatorcontrib><creatorcontrib>Kobus, Hilton J.</creatorcontrib><creatorcontrib>Noel Sims, D.</creatorcontrib><creatorcontrib>Byard, Roger W.</creatorcontrib><creatorcontrib>Lokan, Robert J.</creatorcontrib><creatorcontrib>Stewart Walker, George</creatorcontrib><title>Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood</title><title>Journal of forensic sciences</title><addtitle>J Forensic Sci</addtitle><description>The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high‐performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37°C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7°C, but degraded significantly in inoculated blood at 20 and 37°C. Complete loss occurred within 2 days when incubated at 37°C. The benzisoxazole‐cleaved degradation products for both drugs were identified as 2‐hydroxybenzoyl‐risperidone and 2‐hydroxybenzoyl‐paliperidone utilizing liquid chromatography quadrupole‐time‐of‐flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ.</description><subject>2-hydroxybenzoyl-paliperidone</subject><subject>2-hydroxybenzoyl-risperidone</subject><subject>Animals</subject><subject>Antipsychotic Agents - blood</subject><subject>Bacteria</subject><subject>Blood</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Drug Stability</subject><subject>Drugs</subject><subject>forensic science</subject><subject>Forensic sciences</subject><subject>Forensic Toxicology</subject><subject>Gram-Positive Bacteria - metabolism</subject><subject>Isoxazoles - blood</subject><subject>Mass spectrometry</subject><subject>paliperidone</subject><subject>Paliperidone Palmitate</subject><subject>Postmortem Changes</subject><subject>putrefaction</subject><subject>Pyrimidines - blood</subject><subject>risperidone</subject><subject>Risperidone - analogs & derivatives</subject><subject>Risperidone - blood</subject><subject>Specimen Handling</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Swine</subject><subject>Temperature</subject><issn>0022-1198</issn><issn>1556-4029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFPHCEUx4mp0a31KzST9NLLjDwYBjj0UG3V6qaapsbeCAOMYTs7rLCbrt9epqt78KJcIO_9_o_AD6ECcAV5Hc0qYKwpa0xkRTCQChMicLXeQZNt4x2a4FwuAaTYR-9TmmGMG2hgD-0TImUtBZ6gi2Ntli563Rff3F3UVi99GIrQFb98WuSGDYMr9GCLa937bcEPGTdhvgjJD3fFcR-C_YB2O90nd_i0H6Cb0--_T87L6dXZj5Ov09LUjcAlsbql1NaaM9ZR3DLaguHEWiGNaDvZgnAaG6adJNxYhzUXAqThlnSuNpweoM-buYsY7lcuLdXcJ-P6Xg8urJICSqjAggh4HSWcMmCcNRn99AKdhVUc8kMy1UgGHJqREhvKxJBSdJ1aRD_X8UEBVqMaNVOjATUaUKMa9V-NWufox6cLVu3c2W3w2UUGvmyAf753D28erC5Or8ZTzpebvE9Lt97mdfyrGk45U7c_z9TllPzJc67zLz0CPGOqWA</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Butzbach, Danielle M.</creator><creator>Stockham, Peter C.</creator><creator>Kobus, Hilton J.</creator><creator>Noel Sims, D.</creator><creator>Byard, Roger W.</creator><creator>Lokan, Robert J.</creator><creator>Stewart Walker, George</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K7.</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201301</creationdate><title>Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood</title><author>Butzbach, Danielle M. ; Stockham, Peter C. ; Kobus, Hilton J. ; Noel Sims, D. ; Byard, Roger W. ; Lokan, Robert J. ; Stewart Walker, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4680-2dab33d4a755f30b53b1c72dd89c8bf9b18ea0c5ae927cde0a78819c7d2fe4c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>2-hydroxybenzoyl-paliperidone</topic><topic>2-hydroxybenzoyl-risperidone</topic><topic>Animals</topic><topic>Antipsychotic Agents - blood</topic><topic>Bacteria</topic><topic>Blood</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Drug Stability</topic><topic>Drugs</topic><topic>forensic science</topic><topic>Forensic sciences</topic><topic>Forensic Toxicology</topic><topic>Gram-Positive Bacteria - metabolism</topic><topic>Isoxazoles - blood</topic><topic>Mass spectrometry</topic><topic>paliperidone</topic><topic>Paliperidone Palmitate</topic><topic>Postmortem Changes</topic><topic>putrefaction</topic><topic>Pyrimidines - blood</topic><topic>risperidone</topic><topic>Risperidone - analogs & derivatives</topic><topic>Risperidone - blood</topic><topic>Specimen Handling</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Swine</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butzbach, Danielle M.</creatorcontrib><creatorcontrib>Stockham, Peter C.</creatorcontrib><creatorcontrib>Kobus, Hilton J.</creatorcontrib><creatorcontrib>Noel Sims, D.</creatorcontrib><creatorcontrib>Byard, Roger W.</creatorcontrib><creatorcontrib>Lokan, Robert J.</creatorcontrib><creatorcontrib>Stewart Walker, George</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of forensic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butzbach, Danielle M.</au><au>Stockham, Peter C.</au><au>Kobus, Hilton J.</au><au>Noel Sims, D.</au><au>Byard, Roger W.</au><au>Lokan, Robert J.</au><au>Stewart Walker, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood</atitle><jtitle>Journal of forensic sciences</jtitle><addtitle>J Forensic Sci</addtitle><date>2013-01</date><risdate>2013</risdate><volume>58</volume><issue>1</issue><spage>90</spage><epage>100</epage><pages>90-100</pages><issn>0022-1198</issn><eissn>1556-4029</eissn><coden>JFSCAS</coden><abstract>The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high‐performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at 7, 20 and 37°C for 4 days using sterile and bacterially inoculated porcine blood. The drugs were stable in sterile blood at each temperature and in inoculated blood at 7°C, but degraded significantly in inoculated blood at 20 and 37°C. Complete loss occurred within 2 days when incubated at 37°C. The benzisoxazole‐cleaved degradation products for both drugs were identified as 2‐hydroxybenzoyl‐risperidone and 2‐hydroxybenzoyl‐paliperidone utilizing liquid chromatography quadrupole‐time‐of‐flight mass spectrometry and accurate mass measurements. The degradation products have been found in postmortem case studies, including one case where risperidone and paliperidone were not detected, indicating complete conversion can occur in situ.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>22994980</pmid><doi>10.1111/j.1556-4029.2012.02280.x</doi><tpages>11</tpages></addata></record> |
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| subjects | 2-hydroxybenzoyl-paliperidone 2-hydroxybenzoyl-risperidone Animals Antipsychotic Agents - blood Bacteria Blood Chromatography Chromatography, High Pressure Liquid - methods Drug Stability Drugs forensic science Forensic sciences Forensic Toxicology Gram-Positive Bacteria - metabolism Isoxazoles - blood Mass spectrometry paliperidone Paliperidone Palmitate Postmortem Changes putrefaction Pyrimidines - blood risperidone Risperidone - analogs & derivatives Risperidone - blood Specimen Handling Spectrometry, Mass, Electrospray Ionization Swine Temperature |
| title | Bacterial Degradation of Risperidone and Paliperidone in Decomposing Blood |
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