Roles of 14-3-3η in mitotic progression and its potential use as a therapeutic target for cancers

14-3-3 proteins are involved in several cellular processes, including the G1/S and G2/M cell cycle transitions. However, their roles during mitosis are not well understood. Here, we showed that depletion of 14-3-3η, a 14-3-3 protein isoform, enhanced mitotic cell death, resulting in sensitization to...

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Veröffentlicht in:	Oncogene 2013-03, Vol.32 (12), p.1560-1569
Hauptverfasser:	Lee, C G, Park, G-Y, Han, Y K, Lee, J H, Chun, S H, Park, H-Y, Lim, K-H, Kim, E-G, Choi, Y-J, Yang, K, Lee, C-W
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein 14-3-3 Proteins - antagonists & inhibitors 14-3-3 Proteins - physiology 631/154/555 631/67 631/80/641/1655 Aneuploidy Apoptosis Apoptosis - drug effects Cancer Caspase Caspase 9 - physiology Cell Biology Cell cycle Cell death Cell Division Development and progression Forkhead Box Protein O3 Forkhead Transcription Factors - physiology G2 Phase Genetic aspects HeLa Cells Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Microtubules - drug effects Mitosis Neoplasms - drug therapy Neoplasms - pathology Nocodazole - pharmacology Oncology original-article Physiological aspects Therapeutic targets Tumor cell lines
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