Evidence for reduced dentate gyrus and fimbria volume in bipolar II disorder

Objectives: Dentate gyrus (DG)‐dependent inhibition of the stress response might play an important role in mood disorders. During stress, hippocampal projections traversing the fimbria, a white matter bundle on the hippocampal surface, inhibit the hypothalamic–pituitary–adrenal (HPA) axis. The aim...

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Veröffentlicht in:	Bipolar disorders 2013-03, Vol.15 (2), p.167-176
Hauptverfasser:	Elvsåshagen, Torbjørn, Westlye, Lars T, Bøen, Erlend, Hol, Per K, Andersson, Stein, Andreassen, Ole A, Boye, Birgitte, Malt, Ulrik F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Analysis of Variance Bipolar disorder Bipolar Disorder - pathology bipolar II disorder Case-Control Studies Dentate gyrus Dentate Gyrus - pathology Female Fimbria Fornix Fornix, Brain - pathology Hippocampus Humans Hypothalamic-pituitary-adrenal axis Image processing Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Mood neurogenesis Segmentation Stress Substantia alba Young Adult
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