Lenalidomide efficacy in activated B‐cell‐like subtype diffuse large B‐cell lymphoma is dependent upon IRF4 and cereblon expression

Summary Durable responses with lenalidomide monotherapy have been reported in patients with non‐Hodgkin lymphoma. In relapsed/refractory diffuse large B‐cell lymphoma (DLBCL), higher responses were observed in the activated B‐cell‐like (ABC) subtype than in the germinal centre B‐cell‐like subtype. H...

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Veröffentlicht in:	British journal of haematology 2013-02, Vol.160 (4), p.487-502
Hauptverfasser:	Zhang, Ling‐Hua, Kosek, Jolanta, Wang, Maria, Heise, Carla, Schafer, Peter H., Chopra, Rajesh
Format:	Artikel
Sprache:	eng
Schlagworte:	activated B‐cell‐like Adaptor Proteins, Signal Transducing - drug effects Animals Antineoplastic Agents - pharmacology B-Cell CLL-Lymphoma 10 Protein B-cell lymphoma B-cell receptor Biological and medical sciences CARD Signaling Adaptor Proteins - drug effects CARD Signaling Adaptor Proteins - genetics Caspases - drug effects Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects cereblon diffuse large B‐cell lymphomas Down-Regulation Drug Resistance, Neoplasm - genetics Female Germinal centers Guanylate Cyclase - drug effects Guanylate Cyclase - genetics Hematologic and hematopoietic diseases Humans Interferon regulatory factor 4 Interferon Regulatory Factors - metabolism Interleukin-1 Receptor-Associated Kinases - drug effects Lenalidomide Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - metabolism Medical sciences Mice Mice, SCID Molecular modelling Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Mutation Myeloid Differentiation Factor 88 - drug effects Neoplasm Proteins - drug effects Neoplasm Proteins - metabolism Neoplasm Transplantation - methods NF- Kappa B protein NF-kappa B - drug effects Peptide Hydrolases - metabolism Signal transduction siRNA Thalidomide - analogs & derivatives Thalidomide - pharmacology Transplantation, Heterologous Tumors Ubiquitin-Protein Ligases Xenografts
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