Manipulating Y receptor subtype activation of short neuropeptide Y analogs by introducing carbaboranes

Abstract Short selective neuropeptide Y (NPY) analogs are highly attractive because of their facile synthesis. Based on the reduced-size NPY analog [Pro30 , Nle31 , Bpa32 , Leu34 ]NPY 28–36 position 32 was identified as a key position to alter the preferential activation pattern of the human neurope...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropeptides (Edinburgh) 2013-04, Vol.47 (2), p.59-66
Hauptverfasser:	Hofmann, S, Frank, R, Hey-Hawkins, E, Beck-Sickinger, A.G, Schmidt, P
Format:	Artikel
Sprache:	eng
Schlagworte:	1H NMR Advanced Basic Science Amino Acid Sequence Animals Aromatics Boranes - pharmacology Cells, Cultured Cercopithecus aethiops COS Cells Endocrinology & Metabolism G-Protein coupled receptor HEK293 Cells Humans Magnetic Resonance Spectroscopy Molecular Sequence Data Neuropeptide Y - analogs & derivatives Neuropeptide Y - chemical synthesis Neuropeptide Y - pharmacology Neuropeptide Y analogs ortho-Carbaborane Protein Conformation Receptors, Gastrointestinal Hormone - drug effects Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!