Measles virus selectively blind to signaling lymphocyte activation molecule as a novel oncolytic virus for breast cancer treatment

Oncolytic viruses hold much promise as novel therapeutic agents that can be combined with conventional therapeutic modalities. Measles virus (MV) is known to enter cells using the signaling lymphocyte activation molecule (SLAM), which is expressed on cells of the immune system. Although human breast...

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Veröffentlicht in:	Gene therapy 2013-03, Vol.20 (3), p.338-347
Hauptverfasser:	Sugiyama, T, Yoneda, M, Kuraishi, T, Hattori, S, Inoue, Y, Sato, H, Kai, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/201 631/326/596/1631 692/699/67/1059 692/699/67/1347 Animals Antigens, CD - genetics Antigens, CD - metabolism Antitumor activity Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer Cancer therapies Care and treatment CD150 antigen CD46 antigen Cell activation Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Biology Cell death Cell Line Cell Line, Tumor Cellular biology Cercopithecus aethiops CHO Cells Cricetinae Cricetulus Female Gene Expression Gene Therapy Genetic aspects Health aspects HEK293 Cells Human Genetics Humans Immune system Immunodeficiency Infectivity Lymphocytes Lymphoid cells Macaca fascicularis Macaca mulatta MCF-7 Cells Measles Measles virus Measles virus - genetics Measles virus - metabolism Measles virus - physiology Membrane Cofactor Protein - genetics Membrane Cofactor Protein - metabolism Mice Mice, Inbred BALB C Mice, Nude Nanotechnology Oncolysis Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Oncolytic Viruses - metabolism Oncolytic Viruses - physiology original-article Physiological aspects Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Signal transduction Signaling Lymphocytic Activation Molecule Family Member 1 Tumor cell lines Vaccines Vero Cells Viruses Xenograft Model Antitumor Assays Xenografts
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