The role of bacterial outer membrane vesicles for intra- and interspecies delivery
Summary An increasing number of Gram‐negative bacteria have been observed to secrete outer membrane vesicles (OMVs). Many mysteries remain with respect to OMV formation, the regulation of OMV content and mode of targeting and fusion. Bacterial OMVs appear to serve a variety of purposes in intra‐ and...
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| Veröffentlicht in: | Environmental microbiology 2013-02, Vol.15 (2), p.347-354 |
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| container_title | Environmental microbiology |
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| creator | Berleman, James Auer, Manfred |
| description | Summary
An increasing number of Gram‐negative bacteria have been observed to secrete outer membrane vesicles (OMVs). Many mysteries remain with respect to OMV formation, the regulation of OMV content and mode of targeting and fusion. Bacterial OMVs appear to serve a variety of purposes in intra‐ and interspecies microbial extracellular activities. OMVs have been shown to mediate cell‐to‐cell exchange of DNA, protein and small signalling molecules. The impact of such material exchanges on microbial communities and pathogenic processes, including the delivery of toxins at high concentration through OMVs, is discussed. This rather recent aspect of microbial ecology is likely to remain an important area of research as an in‐depth understanding of OMVs may allow new approaches for combating bacterial infections and provide new routes for selective drug delivery. |
| doi_str_mv | 10.1111/1462-2920.12048 |
| format | Article |
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An increasing number of Gram‐negative bacteria have been observed to secrete outer membrane vesicles (OMVs). Many mysteries remain with respect to OMV formation, the regulation of OMV content and mode of targeting and fusion. Bacterial OMVs appear to serve a variety of purposes in intra‐ and interspecies microbial extracellular activities. OMVs have been shown to mediate cell‐to‐cell exchange of DNA, protein and small signalling molecules. The impact of such material exchanges on microbial communities and pathogenic processes, including the delivery of toxins at high concentration through OMVs, is discussed. This rather recent aspect of microbial ecology is likely to remain an important area of research as an in‐depth understanding of OMVs may allow new approaches for combating bacterial infections and provide new routes for selective drug delivery.</description><identifier>ISSN: 1462-2912</identifier><identifier>EISSN: 1462-2920</identifier><identifier>DOI: 10.1111/1462-2920.12048</identifier><identifier>PMID: 23227894</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Bacteria ; Bacterial Outer Membrane Proteins - metabolism ; Bacterial Proteins - metabolism ; Biological Transport ; DNA, Bacterial - genetics ; Drug Delivery Systems ; Gram-Negative Bacteria - metabolism ; Gram-Negative Bacteria - pathogenicity ; Gram-Negative Bacteria - physiology ; Microbiology</subject><ispartof>Environmental microbiology, 2013-02, Vol.15 (2), p.347-354</ispartof><rights>Published 2012. This article is a U.S. Government work and is in the public domain in the USA</rights><rights>Published 2012. This article is a U.S. Government work and is in the public domain in the USA.</rights><rights>Copyright © 2013 Society for Applied Microbiology and Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5498-5f3d49a616cb6e6d2c271fe2180a6b582b1de0dc2210756cc3987a8900aa910b3</citedby><cites>FETCH-LOGICAL-c5498-5f3d49a616cb6e6d2c271fe2180a6b582b1de0dc2210756cc3987a8900aa910b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1462-2920.12048$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1462-2920.12048$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23227894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berleman, James</creatorcontrib><creatorcontrib>Auer, Manfred</creatorcontrib><title>The role of bacterial outer membrane vesicles for intra- and interspecies delivery</title><title>Environmental microbiology</title><addtitle>Environ Microbiol</addtitle><description>Summary
An increasing number of Gram‐negative bacteria have been observed to secrete outer membrane vesicles (OMVs). Many mysteries remain with respect to OMV formation, the regulation of OMV content and mode of targeting and fusion. Bacterial OMVs appear to serve a variety of purposes in intra‐ and interspecies microbial extracellular activities. OMVs have been shown to mediate cell‐to‐cell exchange of DNA, protein and small signalling molecules. The impact of such material exchanges on microbial communities and pathogenic processes, including the delivery of toxins at high concentration through OMVs, is discussed. This rather recent aspect of microbial ecology is likely to remain an important area of research as an in‐depth understanding of OMVs may allow new approaches for combating bacterial infections and provide new routes for selective drug delivery.</description><subject>Bacteria</subject><subject>Bacterial Outer Membrane Proteins - metabolism</subject><subject>Bacterial Proteins - metabolism</subject><subject>Biological Transport</subject><subject>DNA, Bacterial - genetics</subject><subject>Drug Delivery Systems</subject><subject>Gram-Negative Bacteria - metabolism</subject><subject>Gram-Negative Bacteria - pathogenicity</subject><subject>Gram-Negative Bacteria - physiology</subject><subject>Microbiology</subject><issn>1462-2912</issn><issn>1462-2920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9P2zAcxa0JNFi3827IEhcuWe2vY8c5TvxokToQE4ij5TjfCLOkKXZT6H8_l0IPXPDFz_bnPdl-hPzk7BdPY8xzBRmUkJbAcv2FHO529naawwH5FuMjY7wQBftKDkAAFLrMD8nf2wekoW-R9g2trFti8Lal_ZAE7bCrgp0jXWH0rsVImz5QP18Gm1E7rzcSQ1yg8-msxtavMKy_k_3GthF_vM0jcndxfns6zWbXk8vT37PMybzUmWxEnZdWceUqhaoGBwVvELhmVlVSQ8VrZLUD4KyQyjlR6sLqkjFrS84qMSIn29xF6J8GjEvT-eiwbdON-yEaLkBoBlzln6OgQQvJoEzo8Qf0sR_CPD3kleISmJSJGm8pF_oYAzZmEXxnw9pwZjbNmM3fm00P5rWZ5Dh6yx2qDusd_15FAuQWePYtrj_LM-d_Lt-Ds63PxyW-7Hw2_DMq1S3N_dXEnM2KsxvgUzMR_wHAk6Se</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Berleman, James</creator><creator>Auer, Manfred</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7QL</scope><scope>7ST</scope><scope>7T7</scope><scope>7TN</scope><scope>7U9</scope><scope>7UA</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>The role of bacterial outer membrane vesicles for intra- and interspecies delivery</title><author>Berleman, James ; Auer, Manfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5498-5f3d49a616cb6e6d2c271fe2180a6b582b1de0dc2210756cc3987a8900aa910b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Bacteria</topic><topic>Bacterial Outer Membrane Proteins - metabolism</topic><topic>Bacterial Proteins - metabolism</topic><topic>Biological Transport</topic><topic>DNA, Bacterial - genetics</topic><topic>Drug Delivery Systems</topic><topic>Gram-Negative Bacteria - metabolism</topic><topic>Gram-Negative Bacteria - pathogenicity</topic><topic>Gram-Negative Bacteria - physiology</topic><topic>Microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berleman, James</creatorcontrib><creatorcontrib>Auer, Manfred</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oceanic Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berleman, James</au><au>Auer, Manfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of bacterial outer membrane vesicles for intra- and interspecies delivery</atitle><jtitle>Environmental microbiology</jtitle><addtitle>Environ Microbiol</addtitle><date>2013-02</date><risdate>2013</risdate><volume>15</volume><issue>2</issue><spage>347</spage><epage>354</epage><pages>347-354</pages><issn>1462-2912</issn><eissn>1462-2920</eissn><abstract>Summary
An increasing number of Gram‐negative bacteria have been observed to secrete outer membrane vesicles (OMVs). Many mysteries remain with respect to OMV formation, the regulation of OMV content and mode of targeting and fusion. Bacterial OMVs appear to serve a variety of purposes in intra‐ and interspecies microbial extracellular activities. OMVs have been shown to mediate cell‐to‐cell exchange of DNA, protein and small signalling molecules. The impact of such material exchanges on microbial communities and pathogenic processes, including the delivery of toxins at high concentration through OMVs, is discussed. This rather recent aspect of microbial ecology is likely to remain an important area of research as an in‐depth understanding of OMVs may allow new approaches for combating bacterial infections and provide new routes for selective drug delivery.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23227894</pmid><doi>10.1111/1462-2920.12048</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental microbiology, 2013-02, Vol.15 (2), p.347-354 |
| issn | 1462-2912 1462-2920 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Bacteria Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - metabolism Biological Transport DNA, Bacterial - genetics Drug Delivery Systems Gram-Negative Bacteria - metabolism Gram-Negative Bacteria - pathogenicity Gram-Negative Bacteria - physiology Microbiology |
| title | The role of bacterial outer membrane vesicles for intra- and interspecies delivery |
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