Systematic delineation of optimal cytokine concentrations to expand hematopoietic stem/progenitor cells in co-culture with mesenchymal stem cells

The major obstacle to the widespread use of umbilical cord blood (UCB) in hematopoietic stem/progenitor (HSC) cell therapy is the low cell dose available. A cytokine cocktail for the ex vivo expansion of UCB HSC, in co-culture with a bone marrow (BM) mesenchymal stem cells (MSC)-derived stromal laye...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular bioSystems 2010-01, Vol.6 (7), p.127-1215
Hauptverfasser:	Andrade, Pedro Z, dos Santos, Francisco, Almeida-Porada, Graça, Lobato da Silva, Cláudia, Cabral, Joaquim M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - analysis Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism CD34 antigen Cell culture Cell Culture Techniques Cell number Cell proliferation Cell Proliferation - drug effects Cells, Cultured Coculture Techniques Colony-forming cells Colony-Forming Units Assay Cytokines Cytokines - pharmacology Female Fetal Blood - cytology Fetal Blood - metabolism Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hemopoiesis Humans Membrane Proteins - pharmacology Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchyme Statistics Stem Cell Factor - pharmacology Stem cells Telomeres Thrombopoietin - pharmacology Time Factors Umbilical cord
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!