Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases

Limited understanding of molecular mechanisms of metastasis in melanoma contributes to the absence of effective treatments. Increased knowledge of alterations in genes that underpin critical molecular events that lead to metastasis is essential. We have investigated the gene expression profiles of p...

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Veröffentlicht in:	Modern pathology 2012-06, Vol.25 (6), p.828-837
Hauptverfasser:	Koh, Stephen S, Wei, Jia-Perng J, Li, Xinmin, Huang, Rong R, Doan, Ngan B, Scolyer, Richard A, Cochran, Alistair J, Binder, Scott W
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2217/2018 692/699/67/1813/1634 692/699/67/322 692/700/139/422 Adult Aged Aged, 80 and over Antigens, Neoplasm - genetics Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Cancer Cell cycle Cluster Analysis DNA microarray Female formalin-fixed, paraffin-embedded tissue Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Genomes Genomics Humans Immunohistochemistry Laboratory Medicine Los Angeles Lymph Nodes - chemistry Lymph Nodes - pathology Lymphatic Metastasis Lymphatic system Male Medicine Medicine & Public Health Melanoma Melanoma - chemistry Melanoma - genetics Melanoma - secondary Membrane Proteins - genetics Metastasis Middle Aged Neoplasm Proteins - genetics New South Wales Oligonucleotide Array Sequence Analysis Oncology original-article Paraffin Embedding Pathology Phenotype Principal Component Analysis Reproducibility of Results RNA, Messenger - analysis sentinel lymph node Sentinel Lymph Node Biopsy Skin Neoplasms - chemistry Skin Neoplasms - genetics Skin Neoplasms - pathology Validation studies
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