Cervical lymphadenitis: tuberculosis or tularaemia?
Both tuberculosis cervical lymphadenitis (TCL) and oropharyngeal tularaemia (OT) have similar signs, symptoms and pathological findings. We aimed to investigate the frequency of tularaemia antibodies in patients diagnosed with TCL. Using data from the Tuberculosis Control Dispensaries between the ye...
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| Veröffentlicht in: | Clinical microbiology and infection 2013-02, Vol.19 (2), p.E113-E117 |
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| creator | Karabay, O. Kilic, S. Gurcan, S. Pelitli, T. Karadenizli, A. Bozkurt, H. Bostanci, S. Drancourt, M. |
| description | Both tuberculosis cervical lymphadenitis (TCL) and oropharyngeal tularaemia (OT) have similar signs, symptoms and pathological findings. We aimed to investigate the frequency of tularaemia antibodies in patients diagnosed with TCL. Using data from the Tuberculosis Control Dispensaries between the years of 2008 and 2011 in Turkey, all patients diagnosed with TCL were informed about and included in the study. Control group subjects were selected from healthy blood donors who lived in the same region. After informed consent was obtained, the sera obtained from volunteer TCL patients and the control group were tested with a microagglutination technique for Francisella tularensis. Antibodies to Brucella were also investigated with a tube agglutination test for cross‐reactivity in sera that were seropositive for tularaemia. Sera were obtained from a total of 1170 individuals in the TCL group and 596 in the control group from 67 of 81 provinces in Turkey. Francisella tularensis‐positive antibodies were found in 79 (6.75%) cases in the TCL group and two (0.33%) cases in the control group with a titre of ≥1:80 (p |
| doi_str_mv | 10.1111/1469-0691.12097 |
| format | Article |
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We aimed to investigate the frequency of tularaemia antibodies in patients diagnosed with TCL. Using data from the Tuberculosis Control Dispensaries between the years of 2008 and 2011 in Turkey, all patients diagnosed with TCL were informed about and included in the study. Control group subjects were selected from healthy blood donors who lived in the same region. After informed consent was obtained, the sera obtained from volunteer TCL patients and the control group were tested with a microagglutination technique for Francisella tularensis. Antibodies to Brucella were also investigated with a tube agglutination test for cross‐reactivity in sera that were seropositive for tularaemia. Sera were obtained from a total of 1170 individuals in the TCL group and 596 in the control group from 67 of 81 provinces in Turkey. Francisella tularensis‐positive antibodies were found in 79 (6.75%) cases in the TCL group and two (0.33%) cases in the control group with a titre of ≥1:80 (p < 0.01). When the presence of antibody of any titre was considered, the ratio became 8.2% (96/1170) in the TCL group and 0.67% (4/596) in the control group (p < 0.001). For the first time, with this study, tularaemia serology was found to be positive in a significant portion (6.75%) of diagnosed cases of TCL. In tularaemia endemic regions, it was concluded that tularaemia serology should be investigated in patients suspected of having TCL.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/1469-0691.12097</identifier><identifier>PMID: 23211027</identifier><language>eng</language><publisher>England: Elsevier Limited</publisher><subject>Adult ; Aged ; Agglutination ; Antibodies ; Antibodies, Bacterial - blood ; Blood donors ; Brucella ; Cervical lymphadenitis ; Cross-reactivity ; Data processing ; Female ; Francisella tularensis ; Francisella tularensis - immunology ; Humans ; Lymphadenitis ; Male ; Medical research ; microagglutination test ; Middle Aged ; Mycobacterium ; Neck ; oropharyngeal tularaemia ; Seroepidemiologic Studies ; Serology ; Studies ; Tuberculosis ; Tuberculosis, Lymph Node - complications ; Tuberculosis, Lymph Node - diagnosis ; Tularemia - epidemiology ; Turkey - epidemiology</subject><ispartof>Clinical microbiology and infection, 2013-02, Vol.19 (2), p.E113-E117</ispartof><rights>2012 The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>2012 The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.</rights><rights>Copyright © 2013 European Society of Clinical Microbiology and Infectious Diseases</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1469-0691.12097$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1469-0691.12097$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23211027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karabay, O.</creatorcontrib><creatorcontrib>Kilic, S.</creatorcontrib><creatorcontrib>Gurcan, S.</creatorcontrib><creatorcontrib>Pelitli, T.</creatorcontrib><creatorcontrib>Karadenizli, A.</creatorcontrib><creatorcontrib>Bozkurt, H.</creatorcontrib><creatorcontrib>Bostanci, S.</creatorcontrib><creatorcontrib>Drancourt, M.</creatorcontrib><title>Cervical lymphadenitis: tuberculosis or tularaemia?</title><title>Clinical microbiology and infection</title><addtitle>Clin Microbiol Infect</addtitle><description>Both tuberculosis cervical lymphadenitis (TCL) and oropharyngeal tularaemia (OT) have similar signs, symptoms and pathological findings. We aimed to investigate the frequency of tularaemia antibodies in patients diagnosed with TCL. Using data from the Tuberculosis Control Dispensaries between the years of 2008 and 2011 in Turkey, all patients diagnosed with TCL were informed about and included in the study. Control group subjects were selected from healthy blood donors who lived in the same region. After informed consent was obtained, the sera obtained from volunteer TCL patients and the control group were tested with a microagglutination technique for Francisella tularensis. Antibodies to Brucella were also investigated with a tube agglutination test for cross‐reactivity in sera that were seropositive for tularaemia. Sera were obtained from a total of 1170 individuals in the TCL group and 596 in the control group from 67 of 81 provinces in Turkey. Francisella tularensis‐positive antibodies were found in 79 (6.75%) cases in the TCL group and two (0.33%) cases in the control group with a titre of ≥1:80 (p < 0.01). When the presence of antibody of any titre was considered, the ratio became 8.2% (96/1170) in the TCL group and 0.67% (4/596) in the control group (p < 0.001). For the first time, with this study, tularaemia serology was found to be positive in a significant portion (6.75%) of diagnosed cases of TCL. In tularaemia endemic regions, it was concluded that tularaemia serology should be investigated in patients suspected of having TCL.</description><subject>Adult</subject><subject>Aged</subject><subject>Agglutination</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - blood</subject><subject>Blood donors</subject><subject>Brucella</subject><subject>Cervical lymphadenitis</subject><subject>Cross-reactivity</subject><subject>Data processing</subject><subject>Female</subject><subject>Francisella tularensis</subject><subject>Francisella tularensis - immunology</subject><subject>Humans</subject><subject>Lymphadenitis</subject><subject>Male</subject><subject>Medical research</subject><subject>microagglutination test</subject><subject>Middle Aged</subject><subject>Mycobacterium</subject><subject>Neck</subject><subject>oropharyngeal tularaemia</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Studies</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Lymph Node - complications</subject><subject>Tuberculosis, Lymph Node - diagnosis</subject><subject>Tularemia - epidemiology</subject><subject>Turkey - epidemiology</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbtPwzAQxi0EolCY2VAlFpYUny_xgwWhiJdUxAISm-UkrnDlNCVuQP3vcdrSgYVb7vXTJ919hJwBHUOMK0i5SihXMAZGldgjR7vJfqxByUSk-D4gxyHMKKUMMT0kA4YMgDJxRDC37ZcrjR_5Vb34MJWdu6UL16NlV9i27HwTXBg1bey9aY2tnbk5IQdT44M93eYhebu_e80fk8nLw1N-O0kWCFIkQgqYsopXCMikNGIqM0qVERKk5bzKKJbCYsEiyAHSQlW8ZEUhKXAlFcMhudzoLtrms7NhqWsXSuu9mdumCzrKolCKQvo_yqRASZHRiF78QWdN187jIRoypjgqmvWC51uqK2pb6UXratOu9O_nIpBtgG_n7Wq3B6p7Y3Rvg-5t0GtjdD55Xhf4A0Ame1k</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Karabay, O.</creator><creator>Kilic, S.</creator><creator>Gurcan, S.</creator><creator>Pelitli, T.</creator><creator>Karadenizli, A.</creator><creator>Bozkurt, H.</creator><creator>Bostanci, S.</creator><creator>Drancourt, M.</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Cervical lymphadenitis: tuberculosis or tularaemia?</title><author>Karabay, O. ; Kilic, S. ; Gurcan, S. ; Pelitli, T. ; Karadenizli, A. ; Bozkurt, H. ; Bostanci, S. ; Drancourt, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3187-7871f2d6d313288a7f85009a7818e66d503c7e3b27876114b9d6c2bb801698923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Agglutination</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - blood</topic><topic>Blood donors</topic><topic>Brucella</topic><topic>Cervical lymphadenitis</topic><topic>Cross-reactivity</topic><topic>Data processing</topic><topic>Female</topic><topic>Francisella tularensis</topic><topic>Francisella tularensis - immunology</topic><topic>Humans</topic><topic>Lymphadenitis</topic><topic>Male</topic><topic>Medical research</topic><topic>microagglutination test</topic><topic>Middle Aged</topic><topic>Mycobacterium</topic><topic>Neck</topic><topic>oropharyngeal tularaemia</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Studies</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Lymph Node - complications</topic><topic>Tuberculosis, Lymph Node - diagnosis</topic><topic>Tularemia - epidemiology</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karabay, O.</creatorcontrib><creatorcontrib>Kilic, S.</creatorcontrib><creatorcontrib>Gurcan, S.</creatorcontrib><creatorcontrib>Pelitli, T.</creatorcontrib><creatorcontrib>Karadenizli, A.</creatorcontrib><creatorcontrib>Bozkurt, H.</creatorcontrib><creatorcontrib>Bostanci, S.</creatorcontrib><creatorcontrib>Drancourt, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karabay, O.</au><au>Kilic, S.</au><au>Gurcan, S.</au><au>Pelitli, T.</au><au>Karadenizli, A.</au><au>Bozkurt, H.</au><au>Bostanci, S.</au><au>Drancourt, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical lymphadenitis: tuberculosis or tularaemia?</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2013-02</date><risdate>2013</risdate><volume>19</volume><issue>2</issue><spage>E113</spage><epage>E117</epage><pages>E113-E117</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>Both tuberculosis cervical lymphadenitis (TCL) and oropharyngeal tularaemia (OT) have similar signs, symptoms and pathological findings. We aimed to investigate the frequency of tularaemia antibodies in patients diagnosed with TCL. Using data from the Tuberculosis Control Dispensaries between the years of 2008 and 2011 in Turkey, all patients diagnosed with TCL were informed about and included in the study. Control group subjects were selected from healthy blood donors who lived in the same region. After informed consent was obtained, the sera obtained from volunteer TCL patients and the control group were tested with a microagglutination technique for Francisella tularensis. Antibodies to Brucella were also investigated with a tube agglutination test for cross‐reactivity in sera that were seropositive for tularaemia. Sera were obtained from a total of 1170 individuals in the TCL group and 596 in the control group from 67 of 81 provinces in Turkey. Francisella tularensis‐positive antibodies were found in 79 (6.75%) cases in the TCL group and two (0.33%) cases in the control group with a titre of ≥1:80 (p < 0.01). When the presence of antibody of any titre was considered, the ratio became 8.2% (96/1170) in the TCL group and 0.67% (4/596) in the control group (p < 0.001). For the first time, with this study, tularaemia serology was found to be positive in a significant portion (6.75%) of diagnosed cases of TCL. In tularaemia endemic regions, it was concluded that tularaemia serology should be investigated in patients suspected of having TCL.</abstract><cop>England</cop><pub>Elsevier Limited</pub><pmid>23211027</pmid><doi>10.1111/1469-0691.12097</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Agglutination Antibodies Antibodies, Bacterial - blood Blood donors Brucella Cervical lymphadenitis Cross-reactivity Data processing Female Francisella tularensis Francisella tularensis - immunology Humans Lymphadenitis Male Medical research microagglutination test Middle Aged Mycobacterium Neck oropharyngeal tularaemia Seroepidemiologic Studies Serology Studies Tuberculosis Tuberculosis, Lymph Node - complications Tuberculosis, Lymph Node - diagnosis Tularemia - epidemiology Turkey - epidemiology |
| title | Cervical lymphadenitis: tuberculosis or tularaemia? |
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