Characterization and lectin microarray of an immunomodulatory heteroglucan from Pleurotus ostreatus mycelia

► Glucans isolated from P. ostreatus mycelia have a high mol. wt. of ∼2.7×106Da. ► Glucose, mannose and fucose moieties with β and α linkage form its basic framework. ► Lectin array signify glucose, mannose and fucose residues in terminals and interior. ► The heteroglucan folded into a triple helica...

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Veröffentlicht in:	Carbohydrate polymers 2013-05, Vol.94 (2), p.857-865
Hauptverfasser:	Devi, K. Sanjana P., Roy, Bibhas, Patra, Pradip, Sahoo, Banalata, Islam, Syed S., Maiti, Tapas K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied microbiology Applied sciences Biological and medical sciences Carbohydrate Conformation Cell Survival - drug effects Cells, Cultured Exact sciences and technology Fucose - chemistry Fundamental and applied biological sciences. Psychology Glucans - chemistry Glucans - therapeutic use Glucans - toxicity Glucose - chemistry Heteroglucan Immune Immunologic Factors - chemistry Immunologic Factors - therapeutic use Immunologic Factors - toxicity Immunomodulators Lectin Lectins - chemistry Lectins - metabolism Macrophages - cytology Macrophages - drug effects Macrophages - immunology Mannose - chemistry Medical sciences Mice Microarray Microbiology Miscellaneous Natural polymers Nitric Oxide - metabolism Pharmacology. Drug treatments Physicochemistry of polymers Pleurotus - metabolism Pleurotus ostreatus Sarcoma - drug therapy Sarcoma - immunology Starch and polysaccharides Triple helical
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