Waning immunity to pertussis following 5 doses of DTaP
To assess the risk of pertussis by time since vaccination in children in Minnesota and Oregon who received 5 doses of acellular pertussis vaccines (DTaP). These cohort analyses included Minnesota and Oregon children born between 1998 and 2003 who had 5 DTaP doses recorded in state Immunization Infor...
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| Veröffentlicht in: | Pediatrics (Evanston) 2013-04, Vol.131 (4), p.e1047-e1052 |
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| creator | Tartof, Sara Y Lewis, Melissa Kenyon, Cynthia White, Karen Osborn, Andrew Liko, Juventila Zell, Elizabeth Martin, Stacey Messonnier, Nancy E Clark, Thomas A Skoff, Tami H |
| description | To assess the risk of pertussis by time since vaccination in children in Minnesota and Oregon who received 5 doses of acellular pertussis vaccines (DTaP).
These cohort analyses included Minnesota and Oregon children born between 1998 and 2003 who had 5 DTaP doses recorded in state Immunization Information Systems. Immunization records and statewide pertussis surveillance data were combined. Incidence rates and risk ratios for pertussis were calculated for the 6 years after receipt of the fifth DTaP dose.
The cohorts included 224,378 Minnesota children and 179,011 from Oregon; 458 and 89 pertussis cases were identified in Minnesota and Oregon, respectively. Pertussis incidence rates rose each year of follow-up: 15.6/100,000 (95% confidence interval [CI]: 11.1-21.4) at year 1 to 138.4/100,000 (CI: 113.3-166.9) at year 6 (Minnesota); 6.2/100,000 (CI: 3.3-10.6) in year 1 to 24.4/100,000 (CI: 15.0-37.8) in year 6 (Oregon). Risk ratios increased from 1.9 (CI: 1.3-2.9) in year 2 to 8.9 (CI: 6.0-13.0) in year 6 (Minnesota) and from 1.3 (CI: 0.6-2.8) in year 2 to 4.0 (CI: 1.9-8.4) in year 6 (Oregon).
This evaluation reports steady increase in risk of pertussis in the years after completion of the 5-dose DTaP series. This rise is likely attributable in part to waning immunity from DTaP vaccines. Continuing to monitor disease burden and vaccine effectiveness in fully vaccinated children in coming years will be important to assess ongoing risk as additional cohorts vaccinated solely with acellular pertussis vaccines are introduced. |
| doi_str_mv | 10.1542/peds.2012-1928 |
| format | Article |
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These cohort analyses included Minnesota and Oregon children born between 1998 and 2003 who had 5 DTaP doses recorded in state Immunization Information Systems. Immunization records and statewide pertussis surveillance data were combined. Incidence rates and risk ratios for pertussis were calculated for the 6 years after receipt of the fifth DTaP dose.
The cohorts included 224,378 Minnesota children and 179,011 from Oregon; 458 and 89 pertussis cases were identified in Minnesota and Oregon, respectively. Pertussis incidence rates rose each year of follow-up: 15.6/100,000 (95% confidence interval [CI]: 11.1-21.4) at year 1 to 138.4/100,000 (CI: 113.3-166.9) at year 6 (Minnesota); 6.2/100,000 (CI: 3.3-10.6) in year 1 to 24.4/100,000 (CI: 15.0-37.8) in year 6 (Oregon). Risk ratios increased from 1.9 (CI: 1.3-2.9) in year 2 to 8.9 (CI: 6.0-13.0) in year 6 (Minnesota) and from 1.3 (CI: 0.6-2.8) in year 2 to 4.0 (CI: 1.9-8.4) in year 6 (Oregon).
This evaluation reports steady increase in risk of pertussis in the years after completion of the 5-dose DTaP series. This rise is likely attributable in part to waning immunity from DTaP vaccines. Continuing to monitor disease burden and vaccine effectiveness in fully vaccinated children in coming years will be important to assess ongoing risk as additional cohorts vaccinated solely with acellular pertussis vaccines are introduced.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2012-1928</identifier><identifier>PMID: 23478868</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Care and treatment ; Child ; Child, Preschool ; Children & youth ; Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage ; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology ; Diphtheria-tetanus-pertussis vaccines ; Dosage and administration ; DPT vaccine ; Follow-Up Studies ; Humans ; Immunization ; Immunization Schedule ; Incidence ; Infant ; Minnesota - epidemiology ; Models, Statistical ; Odds Ratio ; Oregon - epidemiology ; Pediatrics ; Population Surveillance ; Risk assessment ; Risk factors ; Time Factors ; Vaccines ; Whooping cough ; Whooping Cough - epidemiology ; Whooping Cough - immunology ; Whooping Cough - prevention & control</subject><ispartof>Pediatrics (Evanston), 2013-04, Vol.131 (4), p.e1047-e1052</ispartof><rights>Copyright American Academy of Pediatrics Apr 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-ad792716989d2a0bf296c4e230e53b76134bba1cdbfd3f246a0ca2c7026a81d43</citedby><cites>FETCH-LOGICAL-c467t-ad792716989d2a0bf296c4e230e53b76134bba1cdbfd3f246a0ca2c7026a81d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23478868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tartof, Sara Y</creatorcontrib><creatorcontrib>Lewis, Melissa</creatorcontrib><creatorcontrib>Kenyon, Cynthia</creatorcontrib><creatorcontrib>White, Karen</creatorcontrib><creatorcontrib>Osborn, Andrew</creatorcontrib><creatorcontrib>Liko, Juventila</creatorcontrib><creatorcontrib>Zell, Elizabeth</creatorcontrib><creatorcontrib>Martin, Stacey</creatorcontrib><creatorcontrib>Messonnier, Nancy E</creatorcontrib><creatorcontrib>Clark, Thomas A</creatorcontrib><creatorcontrib>Skoff, Tami H</creatorcontrib><title>Waning immunity to pertussis following 5 doses of DTaP</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>To assess the risk of pertussis by time since vaccination in children in Minnesota and Oregon who received 5 doses of acellular pertussis vaccines (DTaP).
These cohort analyses included Minnesota and Oregon children born between 1998 and 2003 who had 5 DTaP doses recorded in state Immunization Information Systems. Immunization records and statewide pertussis surveillance data were combined. Incidence rates and risk ratios for pertussis were calculated for the 6 years after receipt of the fifth DTaP dose.
The cohorts included 224,378 Minnesota children and 179,011 from Oregon; 458 and 89 pertussis cases were identified in Minnesota and Oregon, respectively. Pertussis incidence rates rose each year of follow-up: 15.6/100,000 (95% confidence interval [CI]: 11.1-21.4) at year 1 to 138.4/100,000 (CI: 113.3-166.9) at year 6 (Minnesota); 6.2/100,000 (CI: 3.3-10.6) in year 1 to 24.4/100,000 (CI: 15.0-37.8) in year 6 (Oregon). Risk ratios increased from 1.9 (CI: 1.3-2.9) in year 2 to 8.9 (CI: 6.0-13.0) in year 6 (Minnesota) and from 1.3 (CI: 0.6-2.8) in year 2 to 4.0 (CI: 1.9-8.4) in year 6 (Oregon).
This evaluation reports steady increase in risk of pertussis in the years after completion of the 5-dose DTaP series. This rise is likely attributable in part to waning immunity from DTaP vaccines. Continuing to monitor disease burden and vaccine effectiveness in fully vaccinated children in coming years will be important to assess ongoing risk as additional cohorts vaccinated solely with acellular pertussis vaccines are introduced.</description><subject>Care and treatment</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage</subject><subject>Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology</subject><subject>Diphtheria-tetanus-pertussis vaccines</subject><subject>Dosage and administration</subject><subject>DPT vaccine</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>Incidence</subject><subject>Infant</subject><subject>Minnesota - epidemiology</subject><subject>Models, Statistical</subject><subject>Odds Ratio</subject><subject>Oregon - epidemiology</subject><subject>Pediatrics</subject><subject>Population Surveillance</subject><subject>Risk assessment</subject><subject>Risk factors</subject><subject>Time Factors</subject><subject>Vaccines</subject><subject>Whooping cough</subject><subject>Whooping Cough - epidemiology</subject><subject>Whooping Cough - immunology</subject><subject>Whooping Cough - prevention & control</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkT1PwzAQhi0EoqWwMqJILCwp9tmxnRGVT6lSGYoYLcdxqlRJHOJE0H-PQwsD0w333Om9exC6JHhOEga3rc39HDCBmKQgj9CU4FTGDERyjKYYUxIzjJMJOvN-izFmiYBTNAHKhJRcThF_103ZbKKyroem7HdR76LWdv3gfemjwlWV-xz7SZQ7b33kiuh-rV_P0UmhK28vDnWG3h4f1ovneLl6elncLWPDuOhjnYsUBOGpTHPQOCsg5YZZoNgmNBOcUJZlmpg8K3JaAOMaGw1GYOBakpzRGbrZ72079zFY36u69MZWlW6sG7wiFChILCgJ6PU_dOuGrgnpfijOOE8hUPGe2ujKqrIxruntV2_CoXZjVQi_WKm7sDMVIEAGfr7nTee872yh2q6sdbdTBKvRgBoNqNGAGg2EgatDjCGrbf6H_76cfgNsK364</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Tartof, Sara Y</creator><creator>Lewis, Melissa</creator><creator>Kenyon, Cynthia</creator><creator>White, Karen</creator><creator>Osborn, Andrew</creator><creator>Liko, Juventila</creator><creator>Zell, Elizabeth</creator><creator>Martin, Stacey</creator><creator>Messonnier, Nancy E</creator><creator>Clark, Thomas A</creator><creator>Skoff, Tami H</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Waning immunity to pertussis following 5 doses of DTaP</title><author>Tartof, Sara Y ; Lewis, Melissa ; Kenyon, Cynthia ; White, Karen ; Osborn, Andrew ; Liko, Juventila ; Zell, Elizabeth ; Martin, Stacey ; Messonnier, Nancy E ; Clark, Thomas A ; Skoff, Tami H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-ad792716989d2a0bf296c4e230e53b76134bba1cdbfd3f246a0ca2c7026a81d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Care and treatment</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage</topic><topic>Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology</topic><topic>Diphtheria-tetanus-pertussis vaccines</topic><topic>Dosage and administration</topic><topic>DPT vaccine</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>Incidence</topic><topic>Infant</topic><topic>Minnesota - epidemiology</topic><topic>Models, Statistical</topic><topic>Odds Ratio</topic><topic>Oregon - epidemiology</topic><topic>Pediatrics</topic><topic>Population Surveillance</topic><topic>Risk assessment</topic><topic>Risk factors</topic><topic>Time Factors</topic><topic>Vaccines</topic><topic>Whooping cough</topic><topic>Whooping Cough - epidemiology</topic><topic>Whooping Cough - immunology</topic><topic>Whooping Cough - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tartof, Sara Y</creatorcontrib><creatorcontrib>Lewis, Melissa</creatorcontrib><creatorcontrib>Kenyon, Cynthia</creatorcontrib><creatorcontrib>White, Karen</creatorcontrib><creatorcontrib>Osborn, Andrew</creatorcontrib><creatorcontrib>Liko, Juventila</creatorcontrib><creatorcontrib>Zell, Elizabeth</creatorcontrib><creatorcontrib>Martin, Stacey</creatorcontrib><creatorcontrib>Messonnier, Nancy E</creatorcontrib><creatorcontrib>Clark, Thomas A</creatorcontrib><creatorcontrib>Skoff, Tami H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tartof, Sara Y</au><au>Lewis, Melissa</au><au>Kenyon, Cynthia</au><au>White, Karen</au><au>Osborn, Andrew</au><au>Liko, Juventila</au><au>Zell, Elizabeth</au><au>Martin, Stacey</au><au>Messonnier, Nancy E</au><au>Clark, Thomas A</au><au>Skoff, Tami H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Waning immunity to pertussis following 5 doses of DTaP</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2013-04</date><risdate>2013</risdate><volume>131</volume><issue>4</issue><spage>e1047</spage><epage>e1052</epage><pages>e1047-e1052</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>To assess the risk of pertussis by time since vaccination in children in Minnesota and Oregon who received 5 doses of acellular pertussis vaccines (DTaP).
These cohort analyses included Minnesota and Oregon children born between 1998 and 2003 who had 5 DTaP doses recorded in state Immunization Information Systems. Immunization records and statewide pertussis surveillance data were combined. Incidence rates and risk ratios for pertussis were calculated for the 6 years after receipt of the fifth DTaP dose.
The cohorts included 224,378 Minnesota children and 179,011 from Oregon; 458 and 89 pertussis cases were identified in Minnesota and Oregon, respectively. Pertussis incidence rates rose each year of follow-up: 15.6/100,000 (95% confidence interval [CI]: 11.1-21.4) at year 1 to 138.4/100,000 (CI: 113.3-166.9) at year 6 (Minnesota); 6.2/100,000 (CI: 3.3-10.6) in year 1 to 24.4/100,000 (CI: 15.0-37.8) in year 6 (Oregon). Risk ratios increased from 1.9 (CI: 1.3-2.9) in year 2 to 8.9 (CI: 6.0-13.0) in year 6 (Minnesota) and from 1.3 (CI: 0.6-2.8) in year 2 to 4.0 (CI: 1.9-8.4) in year 6 (Oregon).
This evaluation reports steady increase in risk of pertussis in the years after completion of the 5-dose DTaP series. This rise is likely attributable in part to waning immunity from DTaP vaccines. Continuing to monitor disease burden and vaccine effectiveness in fully vaccinated children in coming years will be important to assess ongoing risk as additional cohorts vaccinated solely with acellular pertussis vaccines are introduced.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>23478868</pmid><doi>10.1542/peds.2012-1928</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Care and treatment Child Child, Preschool Children & youth Diphtheria-Tetanus-acellular Pertussis Vaccines - administration & dosage Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology Diphtheria-tetanus-pertussis vaccines Dosage and administration DPT vaccine Follow-Up Studies Humans Immunization Immunization Schedule Incidence Infant Minnesota - epidemiology Models, Statistical Odds Ratio Oregon - epidemiology Pediatrics Population Surveillance Risk assessment Risk factors Time Factors Vaccines Whooping cough Whooping Cough - epidemiology Whooping Cough - immunology Whooping Cough - prevention & control |
| title | Waning immunity to pertussis following 5 doses of DTaP |
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