Concise Synthesis of a Probe Molecule Enabling Analysis and Imaging of Vizantin

Trehalose 6,6′-dicorynomycolate (TDCM) was first characterized in 1963 as a cell surface glycolipid of Corynebacterium spp. by Ioneda and co-workers. TDCM shows potent anti-tumor activity due to its immunoadjuvant properties. Furthermore, the toxicity of TDCM in mice is much weaker than the related...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2013/04/01, Vol.61(4), pp.452-459
Hauptverfasser:	Yamamoto, Hirofumi, Oda, Masataka, Nakano, Mayo, Yabiku, Kenta, Shibutani, Masahiro, Nakanishi, Toshiyuki, Suenaga, Midori, Inoue, Masahisa, Imagawa, Hiroshi, Nagahama, Masahiro, Matsunaga, Yoichi, Himeno, Seiichiro, Setsu, Kojun, Sakurai, Jun, Nishizawa, Mugio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemical synthesis Adjuvants, Immunologic - pharmacokinetics Adjuvants, Immunologic - therapeutic use Animals Cell Line Chemokine CCL4 - metabolism concise synthesis Corynebacterium - chemistry Glycolipids - chemistry Glycolipids - pharmacokinetics Glycolipids - therapeutic use Half-Life Humans Lung Neoplasms - drug therapy Lung Neoplasms - secondary Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Melanoma, Experimental - pathology Mice Molecular Probes - chemistry Molecular Probes - metabolism pharmacokinetics probe molecule Structure-Activity Relationship Trehalose - analogs & derivatives Trehalose - chemistry Trehalose - pharmacokinetics Trehalose - therapeutic use Tumor Necrosis Factor-alpha - metabolism vizantin
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