The Bcl-2/Bcl-xL inhibitor BH3I-2a2 affects the dynamics and subcellular localization of sumoylated proteins

Sumoylation modulates many proteins implicated in apoptosis such as Fas, TNFR1, Daxx, p53 and its regulator MDM2. Some of these proteins, such as DRP-1, are involved in the intrinsic apoptosis pathway. The intrinsic pathway is regulated at the mitochondrial level by the Bcl-2 family of proteins. The...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2013-04, Vol.45 (4), p.826-835
Hauptverfasser:	Plourde, Melodie B, Morchid, Aieda, Iranezereza, Lolita, Berthoux, Lionel
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis
Online-Zugang:	Volltext
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