Mixed-signal template-based reduction scheme for stimulus artifact removal in electrical stimulation
Simultaneous electrical stimulation and recording are used to gain insights into the function of neuronal circuitry. However, artifacts produced by the electrical stimulation pulses prevent the recording of neural responses during, and a short period after, the stimulation duration. In this work, we...
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| Veröffentlicht in: | Medical & biological engineering & computing 2013-04, Vol.51 (4), p.449-458 |
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| creator | Nguyen, Thi Kim Thoa Musa, Silke Eberle, Wolfgang Bartic, Carmen Gielen, Georges |
| description | Simultaneous electrical stimulation and recording are used to gain insights into the function of neuronal circuitry. However, artifacts produced by the electrical stimulation pulses prevent the recording of neural responses during, and a short period after, the stimulation duration. In this work, we describe a mixed-signal recording topology with template subtraction for removing the artifact during the stimulation pulse. Emulated artifacts generated from a lumped electrical circuit model and experimental artifacts in cardiac cell cultures are used to evaluate the topology. The simulations show that delays between the emulated artifact and its estimated compensation template represent the largest error source of the analog template subtraction. The quantization error appears like random noise and determines the threshold level for the action potential detection. Simulations show that removal of the artifacts is possible, allowing the detection of action potentials during the stimulation pulsing period, even for high-amplitude saturating artifacts. Measurement results with artifacts elicited in cardiac cell cultures show feasible applications of this topology. The proposed topology therefore promisingly opens up a previously unavailable detection window for improving the analysis of the neuronal activity. |
| doi_str_mv | 10.1007/s11517-012-1013-6 |
| format | Article |
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However, artifacts produced by the electrical stimulation pulses prevent the recording of neural responses during, and a short period after, the stimulation duration. In this work, we describe a mixed-signal recording topology with template subtraction for removing the artifact during the stimulation pulse. Emulated artifacts generated from a lumped electrical circuit model and experimental artifacts in cardiac cell cultures are used to evaluate the topology. The simulations show that delays between the emulated artifact and its estimated compensation template represent the largest error source of the analog template subtraction. The quantization error appears like random noise and determines the threshold level for the action potential detection. Simulations show that removal of the artifacts is possible, allowing the detection of action potentials during the stimulation pulsing period, even for high-amplitude saturating artifacts. Measurement results with artifacts elicited in cardiac cell cultures show feasible applications of this topology. The proposed topology therefore promisingly opens up a previously unavailable detection window for improving the analysis of the neuronal activity.</description><identifier>ISSN: 0140-0118</identifier><identifier>EISSN: 1741-0444</identifier><identifier>DOI: 10.1007/s11517-012-1013-6</identifier><identifier>PMID: 23242784</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Action Potentials - physiology ; Algorithms ; Animals ; Biomedical and Life Sciences ; Biomedical engineering ; Biomedical Engineering - methods ; Biomedical Engineering and Bioengineering ; Biomedicine ; Cell culture ; Cells, Cultured ; Computer Applications ; Computer Simulation ; Digitization ; Electric Stimulation - methods ; Electrodes ; Human Physiology ; Imaging ; Medical technology ; Models, Neurological ; Myocardium - cytology ; Neurology ; Original Article ; Radiology ; Rats ; Reproducibility of Results ; Signal Processing, Computer-Assisted ; Simulation ; Studies ; Systems analysis ; Topology</subject><ispartof>Medical & biological engineering & computing, 2013-04, Vol.51 (4), p.449-458</ispartof><rights>International Federation for Medical and Biological Engineering 2012</rights><rights>International Federation for Medical and Biological Engineering 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-56d0f65add4b7fd905f055ec709a2b0224c4b22d37545a52486e0e62833e24cc3</citedby><cites>FETCH-LOGICAL-c448t-56d0f65add4b7fd905f055ec709a2b0224c4b22d37545a52486e0e62833e24cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11517-012-1013-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11517-012-1013-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23242784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Thi Kim Thoa</creatorcontrib><creatorcontrib>Musa, Silke</creatorcontrib><creatorcontrib>Eberle, Wolfgang</creatorcontrib><creatorcontrib>Bartic, Carmen</creatorcontrib><creatorcontrib>Gielen, Georges</creatorcontrib><title>Mixed-signal template-based reduction scheme for stimulus artifact removal in electrical stimulation</title><title>Medical & biological engineering & computing</title><addtitle>Med Biol Eng Comput</addtitle><addtitle>Med Biol Eng Comput</addtitle><description>Simultaneous electrical stimulation and recording are used to gain insights into the function of neuronal circuitry. However, artifacts produced by the electrical stimulation pulses prevent the recording of neural responses during, and a short period after, the stimulation duration. In this work, we describe a mixed-signal recording topology with template subtraction for removing the artifact during the stimulation pulse. Emulated artifacts generated from a lumped electrical circuit model and experimental artifacts in cardiac cell cultures are used to evaluate the topology. The simulations show that delays between the emulated artifact and its estimated compensation template represent the largest error source of the analog template subtraction. The quantization error appears like random noise and determines the threshold level for the action potential detection. Simulations show that removal of the artifacts is possible, allowing the detection of action potentials during the stimulation pulsing period, even for high-amplitude saturating artifacts. Measurement results with artifacts elicited in cardiac cell cultures show feasible applications of this topology. The proposed topology therefore promisingly opens up a previously unavailable detection window for improving the analysis of the neuronal activity.</description><subject>Action Potentials - physiology</subject><subject>Algorithms</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical engineering</subject><subject>Biomedical Engineering - methods</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Cell culture</subject><subject>Cells, Cultured</subject><subject>Computer Applications</subject><subject>Computer Simulation</subject><subject>Digitization</subject><subject>Electric Stimulation - methods</subject><subject>Electrodes</subject><subject>Human Physiology</subject><subject>Imaging</subject><subject>Medical technology</subject><subject>Models, Neurological</subject><subject>Myocardium - cytology</subject><subject>Neurology</subject><subject>Original 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However, artifacts produced by the electrical stimulation pulses prevent the recording of neural responses during, and a short period after, the stimulation duration. In this work, we describe a mixed-signal recording topology with template subtraction for removing the artifact during the stimulation pulse. Emulated artifacts generated from a lumped electrical circuit model and experimental artifacts in cardiac cell cultures are used to evaluate the topology. The simulations show that delays between the emulated artifact and its estimated compensation template represent the largest error source of the analog template subtraction. The quantization error appears like random noise and determines the threshold level for the action potential detection. Simulations show that removal of the artifacts is possible, allowing the detection of action potentials during the stimulation pulsing period, even for high-amplitude saturating artifacts. 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| subjects | Action Potentials - physiology Algorithms Animals Biomedical and Life Sciences Biomedical engineering Biomedical Engineering - methods Biomedical Engineering and Bioengineering Biomedicine Cell culture Cells, Cultured Computer Applications Computer Simulation Digitization Electric Stimulation - methods Electrodes Human Physiology Imaging Medical technology Models, Neurological Myocardium - cytology Neurology Original Article Radiology Rats Reproducibility of Results Signal Processing, Computer-Assisted Simulation Studies Systems analysis Topology |
| title | Mixed-signal template-based reduction scheme for stimulus artifact removal in electrical stimulation |
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