Application of simple biomechanical and biochemical tests to heart valve leaflets: Implications for heart valve characterization and tissue engineering
A simple biomechanical test with real-time displacement and strain mapping is reported, which provides displacement vectors and principal strain directions during the mechanical characterization of heart valve tissues. The maps reported in the current study allow us to quickly identify the approxima...
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| Veröffentlicht in: | Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine Journal of engineering in medicine, 2012-11, Vol.226 (11), p.868-876 |
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| container_title | Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine |
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| creator | Huang, Hsiao-Ying S Balhouse, Brittany N Huang, Siyao |
| description | A simple biomechanical test with real-time displacement and strain mapping is reported, which provides displacement vectors and principal strain directions during the mechanical characterization of heart valve tissues. The maps reported in the current study allow us to quickly identify the approximate strain imposed on a location in the samples. The biomechanical results show that the aortic valves exhibit stronger anisotropic mechanical behavior than that of the pulmonary valves before 18% strain equibiaxial stretching. In contrast, the pulmonary valves exhibit stronger anisotropic mechanical behavior than aortic valves beyond 28% strain equibiaxial stretching. Simple biochemical tests are also conducted. Collagens are extracted at different time points (24, 48, 72, and 120 h) at different locations in the samples. The results show that extraction time plays an important role in determining collagen concentration, in which a minimum of 72 h of extraction is required to obtain saturated collagen concentration. This work provides an easy approach for quantifying biomechanical and biochemical properties of semilunar heart valve tissues, and potentially facilitates the development of tissue engineered heart valves. |
| doi_str_mv | 10.1177/0954411912455004 |
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The maps reported in the current study allow us to quickly identify the approximate strain imposed on a location in the samples. The biomechanical results show that the aortic valves exhibit stronger anisotropic mechanical behavior than that of the pulmonary valves before 18% strain equibiaxial stretching. In contrast, the pulmonary valves exhibit stronger anisotropic mechanical behavior than aortic valves beyond 28% strain equibiaxial stretching. Simple biochemical tests are also conducted. Collagens are extracted at different time points (24, 48, 72, and 120 h) at different locations in the samples. The results show that extraction time plays an important role in determining collagen concentration, in which a minimum of 72 h of extraction is required to obtain saturated collagen concentration. This work provides an easy approach for quantifying biomechanical and biochemical properties of semilunar heart valve tissues, and potentially facilitates the development of tissue engineered heart valves.</description><identifier>ISSN: 0954-4119</identifier><identifier>EISSN: 2041-3033</identifier><identifier>DOI: 10.1177/0954411912455004</identifier><identifier>PMID: 23185957</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Biochemistry ; Biomechanics ; Collagen ; Collagen - physiology ; Equipment Design ; Equipment Failure Analysis ; Heart ; Heart Valves - anatomy & histology ; Heart Valves - physiology ; Mapping ; Physical Stimulation - instrumentation ; Physical Stimulation - methods ; Real time ; Swine ; Tissue engineering ; Tissue Engineering - instrumentation</subject><ispartof>Proceedings of the Institution of Mechanical Engineers. 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Part H, Journal of engineering in medicine</title><addtitle>Proc Inst Mech Eng H</addtitle><description>A simple biomechanical test with real-time displacement and strain mapping is reported, which provides displacement vectors and principal strain directions during the mechanical characterization of heart valve tissues. The maps reported in the current study allow us to quickly identify the approximate strain imposed on a location in the samples. The biomechanical results show that the aortic valves exhibit stronger anisotropic mechanical behavior than that of the pulmonary valves before 18% strain equibiaxial stretching. In contrast, the pulmonary valves exhibit stronger anisotropic mechanical behavior than aortic valves beyond 28% strain equibiaxial stretching. Simple biochemical tests are also conducted. Collagens are extracted at different time points (24, 48, 72, and 120 h) at different locations in the samples. The results show that extraction time plays an important role in determining collagen concentration, in which a minimum of 72 h of extraction is required to obtain saturated collagen concentration. This work provides an easy approach for quantifying biomechanical and biochemical properties of semilunar heart valve tissues, and potentially facilitates the development of tissue engineered heart valves.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomechanics</subject><subject>Collagen</subject><subject>Collagen - physiology</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Heart</subject><subject>Heart Valves - anatomy & histology</subject><subject>Heart Valves - physiology</subject><subject>Mapping</subject><subject>Physical Stimulation - instrumentation</subject><subject>Physical Stimulation - methods</subject><subject>Real time</subject><subject>Swine</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - instrumentation</subject><issn>0954-4119</issn><issn>2041-3033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFTEUxYMo9lndu5KAm25G83cy466UqoWCG10PSebmvZTMZEwyBf0ifl0zvlq0IJJFyD2_ey43B6GXlLyhVKm3pJdCUNpTJqQkRDxCO0YEbTjh_DHabXKz6SfoWc43hBBKSfsUnTBOO9lLtUM_zpcleKuLjzOODmc_LQGw8XECe9BzlQLW87hV7AGmX-8CuWRcIj6ATgXf6nALOIB2AUp-h6-me8uMXUx_YdU0aVsg-e_HoZt58TmvgGHe-xmqNO-foydOhwwv7u5T9OX95eeLj831pw9XF-fXjRWClEZKGMF2BtrWdaPWxnHHnGlHw7QBACV7S_qRAe2sskKpjggBnTOGGM6Z4qfo7Oi7pPh1rXsNk88WQtAzxDUPlLN6KGu7_6OMEdXz-rEVff0AvYlrmusiAyV9q5gUXFSKHCmbYs4J3LAkP-n0rULDlu_wMN_a8urOeDUTjPcNvwOtQHMEst7Dn1P_YfgTSgWwPA</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Huang, Hsiao-Ying S</creator><creator>Balhouse, Brittany N</creator><creator>Huang, Siyao</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Application of simple biomechanical and biochemical tests to heart valve leaflets: Implications for heart valve characterization and tissue engineering</title><author>Huang, Hsiao-Ying S ; 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| subjects | Animals Biochemistry Biomechanics Collagen Collagen - physiology Equipment Design Equipment Failure Analysis Heart Heart Valves - anatomy & histology Heart Valves - physiology Mapping Physical Stimulation - instrumentation Physical Stimulation - methods Real time Swine Tissue engineering Tissue Engineering - instrumentation |
| title | Application of simple biomechanical and biochemical tests to heart valve leaflets: Implications for heart valve characterization and tissue engineering |
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