RP-HPLC assay of doxycycline in human saliva and gingival crevicular fluid in patients with chronic periodontal disease

[Display omitted] ► RP-HPLC-FLD method for determination of doxycycline was developed and validated. ► Tetracycline was used as internal standard. ► The simple extraction with ACN without the sample concentration was described. ► The proposed method was successfully applied to the analysis of DOXY i...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2013-05, Vol.78-79, p.170-175
Hauptverfasser:	Denić, Marko S., Sunarić, Slavica M., Kesić, Ljiljana G., Minić, Ivan Z., Obradović, Radmila R., Denić, Marija S., Petrović, Milica S.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetates acetonitrile ammonium acetate ammonium hydroxide Chromatography, High Pressure Liquid - methods Chronic Disease Doxycycline Doxycycline - analysis Doxycycline - therapeutic use fluorescence Gingival crevicular fluid Gingival Crevicular Fluid - chemistry HPLC Humans Limit of Detection magnesium patients periodontal diseases Periodontal Diseases - drug therapy Reproducibility of Results reversed-phase high performance liquid chromatography Saliva Saliva - chemistry salts Spectrometry, Fluorescence tetracycline
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