Pharmacokinetics and tissue distribution study of schisandrin B in rats by ultra-fast liquid chromatography with tandem mass spectrometry

The concentration–time profile of schisandrin B in tissues after oral administration at a dose of 4mg/kg to rats (n=6). [Display omitted] ► Development of an UFLC–MS/MS method to determine schisandrin B in biological matrix. ► Pharmacokinetic curve of schisandrin B showed double peaks in rat plasma....

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2013-05, Vol.78-79, p.136-140
Hauptverfasser:	Zhu, Heyun, Zhang, Xiurong, Guan, Jiao, Cui, Baiji, Zhao, Longshan, Zhao, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Liquid - methods Cyclooctanes - pharmacokinetics Lignans - pharmacokinetics Pharmacokinetics Polycyclic Compounds - pharmacokinetics Protein precipitation Rats Reference Standards Reproducibility of Results Schisandrin B Tandem Mass Spectrometry - methods Tissue Distribution UFLC–MS/MS
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