Patients with cystic fibrosis have inducible IL-17+ IL-22+ memory cells in lung draining lymph nodes

Background IL-17 is an important cytokine signature of the TH differentiation pathway TH 17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. Objective We set ou...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2013-04, Vol.131 (4), p.1117-1129.e5
Hauptverfasser:	Chan, Yvonne R., MD, Chen, Kong, PhD, Duncan, Steven R., MD, Lathrop, Kira L., MAMS, Latoche, Joseph D., BS, Logar, Alison J., BS, Pociask, Derek A., PhD, Wahlberg, Brendon J., MS, Ray, Prabir, PhD, Ray, Anuradha, PhD, Pilewski, Joseph M., MD, Kolls, Jay K., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Allergy and Immunology Antigens Antigens, Bacterial - immunology Antigens, Bacterial - pharmacology Antigens, Fungal - immunology Antigens, Fungal - pharmacology Aspergillus - chemistry Aspergillus species Biological and medical sciences Case-Control Studies Cell Proliferation - drug effects chronic infectious disease Chronic obstructive pulmonary disease Cystic fibrosis Cystic Fibrosis - genetics Cystic Fibrosis - immunology Cystic Fibrosis - pathology Disease Errors of metabolism Female Fundamental and applied biological sciences. Psychology Fundamental immunology Fungal infections Gene Expression Human subjects Humans IL-17 IL-22 Immune system Immunologic Memory Immunopathology Immunophenotyping Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-22 Interleukins - genetics Interleukins - immunology Lung - drug effects Lung - immunology Lung - pathology lung transplant Lungs Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - pathology Lymphocyte Activation - drug effects Male Medical sciences memory T-cell response Metabolic diseases Middle Aged Miscellaneous hereditary metabolic disorders Pseudomonas aeruginosa - chemistry Pseudomonas species Review boards Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Studies TH17 Th17 Cells - drug effects Th17 Cells - immunology Th17 Cells - pathology TH22 Transplants & implants
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