High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer

Abstract Cell-mediated immunity may impact prostate cancer progression and has great therapeutic potential. Here, we investigated the clinical significance of the numeric density of regulatory T cells (Tregs) in prostate cancer as the presence of such cells in the tumour microenvironment has been li...

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Veröffentlicht in:	European journal of cancer (1990) 2013-04, Vol.49 (6), p.1273-1279
Hauptverfasser:	Flammiger, Anna, Weisbach, Lars, Huland, Hartwig, Tennstedt, Pierre, Simon, Ronald, Minner, Sarah, Bokemeyer, Carsten, Sauter, Guido, Schlomm, Thorsten, Trepel, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Androgen Antagonists - therapeutic use Biological and medical sciences Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism FOXP3 Hematology, Oncology and Palliative Medicine Humans Immunity, Cellular - immunology Immunohistochemistry Kaplan-Meier Estimate Ki-67 Antigen - immunology Ki-67 Antigen - metabolism Lymphocyte Count Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Grading Neoplasm Staging Outcome Assessment (Health Care) - statistics & numerical data Pharmacology. Drug treatments Preoperative Period Prognosis Proportional Hazards Models Prostate cancer Prostate-Specific Antigen - immunology Prostate-Specific Antigen - metabolism Prostatectomy - methods Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy PSA recurrence free survival Regulatory T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tissue Array Analysis Tissue microarray Tumors
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