Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans

Efforts to selectively target and disrupt established tumor vasculature have largely failed to date. We hypothesized that a vaccinia virus engineered to target cells with activation of the ras/MAPK signaling pathway (JX-594) could specifically infect and express transgenes (hGM-CSF, β-galactosidase)...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-02, Vol.73 (4), p.1265-1275
Hauptverfasser:	BREITBACH, Caroline J, ARULANANDAM, Rozanne, HEO, Jeong, CHO, Mong, CHEN, Hannah, ANGARITA, Fernando A, ADDISON, Christina, ANDREA MCCART, J, BELL, John C, KIRN, David H, DE SILVA, Naomi, THORNE, Steve H, PATT, Richard, DANESHMAND, Manijeh, MOON, Anne, ILKOW, Carolina, BURKE, James, HWANG, Tae-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Blotting, Western Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - therapy Carcinoma, Hepatocellular - virology Cell Line, Tumor Cells, Cultured Clinical Trials, Phase I as Topic Endothelial Cells - drug effects Endothelial Cells - physiology Endothelial Cells - virology Female Fibroblast Growth Factor 2 - pharmacology Humans Liver Neoplasms - blood supply Liver Neoplasms - therapy Liver Neoplasms - virology Magnetic Resonance Imaging Medical sciences Mice Mice, Inbred BALB C Neoplasms, Experimental - blood supply Neoplasms, Experimental - therapy Neoplasms, Experimental - virology Neovascularization, Pathologic - prevention & control Neovascularization, Pathologic - virology Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Oncolytic Viruses - physiology Pharmacology. Drug treatments Rabbits Receptors, Vascular Endothelial Growth Factor - metabolism Time Factors Treatment Outcome Tumors Vaccinia virus - genetics Vaccinia virus - physiology Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - pharmacology Virus Replication
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